Recent Advances in Palladium-Catalyzed Asymmetric Hydroesterification of Alkenes

doi:10.6023/cjoc202509035

Abstract

Asymmetric hydroesterification has become one of the most attractive pathways for synthesizing chiral carboxylic acid derivatives due to its atom economy and step simplicity. The core challenge of this reaction lies in the simultaneous achievement of synergistic control over high chemo-, regio-, and enantioselectivity. Chiral ligands, as key components of the catalytic system, directly govern the catalytic efficiency and stereochemical control of the reaction by precisely modulating the stereoelectronic properties and coordination environment of the transition metal active center. This review systematically summarizes the research progress over decades in palladium-catalyzed asymmetric hydroesterification of alkenes, critically evaluates the breakthrough contributions of innovative chiral ligand design to selectivity control, and discusses the challenges and future development directions in this field.

Key words: chiral ligands, asymmetric, hydroesterification, palladium-catalyzed

Cite this article

Feng, Kai, He, ZhaoBo, Wang, Zhen. Recent Advances in Palladium-Catalyzed Asymmetric Hydroesterification of Alkenes[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202509035.

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