t-Butyl Hydroperoxide-Promoted Three-Component Reaction of Quinoxalin-2(1H)-ones, N-Phenylglycines and Paraformaldehyde: an Efficient Approach to Tetrahydroimidazo-[1,5-a]quinoxalin-4(5H)-ones

doi:10.6023/cjoc202601030

Chinese Journal of Organic Chemistry ›› 2026, Vol. 46 ›› Issue (4): 1668-1676.DOI: 10.6023/cjoc202601030 Previous Articles Next Articles

ARTICLES

叔丁基过氧化氢促进喹喔啉酮、N-芳基甘氨酸和多聚甲醛的三组分反应: 高效合成四氢咪唑并[1,5-a]喹喔啉酮

李婷^a, 欧阳文韬^a, 易荣楠^b^,^*(), 唐欲才^c, 杨梓^d^,^*(), 吴超^a^,^*(), 何卫民^a^,^*()

^a 南华大学化学化工学院湖南衡阳 421001
^b 湖南警察学院食药环及毒品检验技术湖南省普通高等学校重点实验室食药环及毒品检验技术湖南省普通高等学校重点实验室长沙 410138
^c 湖南文理学院化学与材料工程学院湖南常德 415000
^d 长沙医学院功能核酸基础与临床湖南省普通高校重点实验室功能核酸基础与临床湖南省普通高校重点实验室长沙 410219

收稿日期:2026-01-20 修回日期:2026-03-31 发布日期:2026-04-13
通讯作者: 易荣楠, 杨梓, 吴超, 何卫民
基金资助:
湖南省自然科学基金(2026JJ90135); 湖南省教育厅科学研究(25A0703); 长沙市自然科学基金(104872)

t-Butyl Hydroperoxide-Promoted Three-Component Reaction of Quinoxalin-2(1H)-ones, N-Phenylglycines and Paraformaldehyde: an Efficient Approach to Tetrahydroimidazo-[1,5-a]quinoxalin-4(5H)-ones

Ting Li^a, Wentao Ouyang^a, Rongnan Yi^b^,^*(), Yucai Tang^c, Zi Yang^d^,^*(), Chao Wu^a^,^*(), Weimin He^a^,^*()

^a School of Chemistry and Chemical Engineering, University of South China, Hengyang, Hunan 421001
^b Key Laboratory of Food & Environment & Drug Monitoring and Testing of Universities in Hunan Province, Hunan Police Academy, Changsha 410138
^c College of Chemistry and Materials Engineering, Hunan University of Arts and Science, Changde, Hunan 415000
^d Hunan Provincial University Key Laboratory of the Fundamental and Clinical Research on Functional Nucleic Acid, Changsha Medical University, Changsha 410219

Received:2026-01-20 Revised:2026-03-31 Published:2026-04-13
Contact: Rongnan Yi, Zi Yang, Chao Wu, Weimin He
Supported by:
Hunan Provincial Natural Science Foundation(2026JJ90135); Scientific Research Fund of Hunan Provincial Education Department(25A0703); Changsha Natural Science Foundation(104872)

1. .pdf(4225KB)

Abstract

C3-Functionalized quinoxalin-2(1H)-ones generally exhibit promising biological activities and pharmacological values. Currently, a series of C3-functionalized quinoxalin-2(1H)-ones bearing alkyl, aryl, amino, fluoroalkyl, acyl, and phosphoryl groups have been synthesized through the C3—H functionalization strategy. However, reports on the construction of fused-heterocycles incorporating a quinoxalinone skeleton via a cascade cyclization reaction initiated by C3—H activation remain relatively limited. Herein, an efficient multi-component synthetic protocol was reported using low-cost, readily available t-butyl hydroperoxide as the oxidant and paraformaldehyde as the C1 synthon, enabling the synthesis of a series of tetrahydroimidazo[1,5-a]quinoxalin-4(5H)-ones. This reaction proceeds without the need for special apparatus under ambient air, featuring mild conditions, simple operation, and low cost. This strategy holds great potential as a practical approach for the synthesis of tetrahydroimidazoquinoxalinone compounds.

Key words: quinoxalin-2(1H)-ones, N-phenylglycines, paraformaldehyde, decarboxylation, cyclization reaction

Cite this article

Ting Li, Wentao Ouyang, Rongnan Yi, Yucai Tang, Zi Yang, Chao Wu, Weimin He. t-Butyl Hydroperoxide-Promoted Three-Component Reaction of Quinoxalin-2(1H)-ones, N-Phenylglycines and Paraformaldehyde: an Efficient Approach to Tetrahydroimidazo-[1,5-a]quinoxalin-4(5H)-ones[J]. Chinese Journal of Organic Chemistry, 2026, 46(4): 1668-1676.

Export EndNote|Reference Manager|ProCite|BibTeX|RefWorks

share this article

Fig. & Tab. 5

References 14

[5]	(h) Ma, Z.; Cui, H.; Wei, W.; Yue, H.; Gong, Y.; Yang, Z.; Wang, Z.; Yi, D. J. Org. Chem. 2026, 91, 732.
	(i) Zhao, F.; Ding, H.; Sun, T.; Shen, C.; Wang, Z.-L.; Wei, W.; Yi, D. Chin. Chem. Lett. 2026, 37, 111834.
	(j) Xu, J.; Zhang, J.; Wang, Z.; Li, J.; Shen, J.; Zhang, P. Org. Lett. 2026, 28, 2777.
[6]	(a) Shao, T.; Ban, X.; Jiang, Z. Chem. Rec. 2023, 23, e202300122.
	(b) Wei, J.; Yang, H.; He, Q.; Wang, T.; Cheng, B. Chem. Asian J. 2025, 20, e00153.
	(c) Wen, J.; Ma, J.; Yan, K.; Zhang, X.; Huang, K.; Wu, L.; Li, D.; Yang, J. ACS Sustainable Chem. Eng. 2023, 11, 16785.
	(d) Zhou, X.; Zhang, B.; Wu, P.; Xu, W.; Wang, R.; Li, J.; Zhai, H.; Cheng, B.; Wang, T. Org. Lett. 2023, 25, 7512.
[1]	(a) Jiang, X.; Wu, K.; Bai, R.; Zhang, P.; Zhang, Y. Eur. J. Med. Chem. 2022, 229, 114085
	(b) Peng, L.; Gao, J. K.; Yang, Z. Y.; Ai, X. Y.; Liang, W. IEEE J Biomed. Health 2026, DOI: 10.1109/JBHI.2026.3662042.
	(c) Alhuwayshil, J.; Alnajim, N.; Dulaym, S. b.; Alamre, J.; Alsubait, A.; Mohammed, A. E.; Alghamdi, S. S. Biomol. Ther. 2026, 34, 291.
[2]	(a) Dong, J.; Xuan, L.; Wang, C.; Zhao, C.; Wang, H.; Yan, Q.; Wang, W.; Chen, F. Chin. J. Org. Chem. 2024, 44, 111 (in Chinese).
	(董江湖, 宣良明, 王池, 赵晨熙, 王海峰, 严琼姣, 汪伟, 陈芬儿, 有机化学, 2024, 44, 111.)
	(b) Zhang, Z.; Cheng, F.; Ma, X.; Sun, K.; Huang, X.; An, J.; Peng, M.; Chen, X.; Yu, B. Green Chem. 2024, 26, 7331.
[6]	(e) Song, T.-T.; Mei, Y.-K.; Liu, Y.; Wang, X.-Y.; Guo, S.-Y.; Ji, D.-W.; Wan, B.; Yuan, W.; Chen, Q.-A. Angew. Chem. Int. Ed. 2024, 63, e202314304.
	(f) Guo, C.; Zhao, G.; Feng, Y.; Chen, D.; Loh, T.-P.; Wang, D.; Jia, Z. Org. Chem. Front. 2025, 12, 2409.
[7]	7., Cui,J.-F.; Zhong, W.-Q.; Huang, J. -M. J. Org. Chem. 2023, 88, 1147.
[8]	Lu, Y.-H.; Zhang, Z.-T.; Wu, H.-Y.; Zhou, M.-H.; Song, H.-Y.; Ji, H.-T.; Jiang, J.; Chen, J.-Y.; He, W.-M. Chin. Chem. Lett. 2023, 34, 108036.
[9]	(a) Deng, S.; Peng, C.; Niu, Y.; Xu, Y.; Zhang, Y.; Chen, X.; Wang, H.; Liu, S.; Shen, X. Acta Chim. Sinica 2024, 82, 119 (in Chinese).
	(邓沈娜, 彭常春, 牛云宏, 许云, 张云霄, 陈祥, 王红敏, 刘珊珊, 沈晓, 化学学报, 2024, 82, 119.)
	(b) Peng, Q.-H.; Peng, J.; Cai, Y.-L.; Wang, Z.-L.; Yi, R.-N.; Shen, C.; He, W.-M. Acta Chim. Sinica 2025, 83, 1013 (in Chinese).
	(彭琼慧, 彭佳, 蔡迎丽, 王祖利, 易荣楠, 沈超, 何卫民, 化学学报, 2025, 83, 1013.)
	(c) Cao, S.; Guo, H.; Zhong, Z.; Chen, D.; Song, W.; Liu, Y.; Wan, J.-P. Sci. Adv. 2025, 11, eaea4120.
	(d) Feng, Y.; Huang, J.; Wang, Y.; Sun, J.; Nan, G.; Wei, W. Chin. J. Org. Chem. 2025, 45, 3912 (in Chinese).
	(冯亚萍, 黄健, 王英杰, 孙健, 南光明, 魏伟, 有机化学, 2025, 45, 3912.)
	(e) Chen, B.; Xu, J.; Wang, Z.; Yang, L.; Liu, Q.; Zhang, P. Green Chem. 2025, 27, 10656.
	(f) Jin, Y.; Mu, H.; Sun, Y.; Wang, L.; Jin, Y. Chin. J. Org. Chem. 2025, 45, 4443 (in Chinese).
	(金言, 穆宏文, 孙玉虹, 王黎明, 金瑛, 有机化学, 2025, 45, 4443.)
	(g) Wang, Y.; Wang, J.; Chen, C.; Song, L.; Wang, Z.-L.; Wei, W.; Yi, D. Chem. Commun. 2025, 61, 10812.
	(h) Lv, Y.; Song, L.; Yue, H.; Wang, Z.; Wei, W. Chin. Chem. Lett. 2025, 37, 112309.
	(i) Ye, J.; Li, G.; Wan, C.; Wan, J.-P. Org. Chem. Front. 2026, 13, 106.
[10]	(a) Lei, S.-G.; Zhou, Y.; Wang, L.-S.; Yu, Z.-C.; Chen, T.; Wu, Y.-D.; Gao, M.; Wu, A.-X. J. Org. Chem. 2023, 88, 11150.
	(b) Song, H.-Y.; Jiang, J.; Song, Y.-H.; Zhou, M.-H.; Wu, C.; Chen, X.; He, W.-M. Chin. Chem. Lett. 2024, 35, 109246.
	(c) Nayak, M. K.; Chakraborty, S.; Mohanty, A.; Roy, S. Org. Biomol. Chem. 2024, 22, 5768.
	(d) Bi, S.; Mao, X.-D.; Schmoll, A.; Wu, X.-F. Chem.-Asian J. 2025, 20, e202401742.
	(e) Wang, L.; Hu, Y.; Pu, Q.; Yao, Y.; Zhang, H.; Guo, Y.; Li, Y.; Dai, B.; Ke, Z. RSC Sustainability 2025, 3, 395.
[11]	(a) Qi, Z.; Wen, S.; Hao, L.; Liu, S.; Jiang, D. Org. Lett. 2023, 25, 7322.
	(b) Qi, Z.; Wen, S.; Liu, Z.; Jiang, D. Org. Lett. 2023, 25, 6110.
	(c) Qi, Z.; Wen, S.-M.; Wu, Q.; Jiang, D.-F.; Hao, W.-J.; Jiang, B. J. Org. Chem. 2023, 88, 11874.
	(d) Wang, Y.; Li, R.; Huang, J.; Jia, F.; Wang, Z.; Wei, W.; Yang, Z.; Yi, D. Chem. Commun. 2025, 61, 17137.
	(e) Wang, Q.-L.; He, C.; Yang, K.-Q.; Hu, X.-M.; Li, W.; Yang, Z.; Yu, M.; Cai, J. J. Org. Chem. 2025, 90, 15819.
	(f) Zeng, Z.; Zhao, F.; Zhong, H.; Yang, Z.; Wei, H.; Ji, S.; Yu, M.; Cai, J. J. Org. Chem. 2025, 90, 15345.
	(g) Huang, J.; Li, R.; Lv, Y.; Jia, F.; Yue, H.; Yang, Z.; Wang, Z.; Wei, W.; Yi, D. J. Org. Chem. 2025, 90, 14805.
[2]	(c) Cui, H.; Ma, Z.; Yue, H.; Xia, H.; Wei, W.; Yang, Z.; Wang, Z.; Yi, D. J. Org. Chem. 2025, 90, 18092.
	(d) Cui, H.; Qiao, X.; Shi, T.; Wei, W.; Yue, H.; Wang, Z.; Ma, Z.; Yang, Z. Chem. Commun. 2025, 61, 17890.
	(e) Wen, Y.-C.; Hou, J.-C.; Zhou, Q.; Wang, S.-H.; Jiang, J.; Yang, Z.; Zhu, H.-T.; Wang, Z.-L.; He, W.-M. Chin. Chem. Lett. 2025, 36, 111795.
	(f) Huang, J.; Chen, J. Chin. J. Org. Chem. 2025, 45, 4236 (in Chinese).
	(黄静, 陈加荣, 有机化学, 2025, 45, 4236.)
	(g) Zeng, Y.-Y.; Jiang, J.; Wen, Y.-C.; Zhuang, C.-L.; Ou, L.-J.; Yang, Z.; Zhu, H.-T.; Wang, Z.-L.; He, W.-M. Chin. Chem. Lett. 2026, 37, 111776.
[3]	Si, Y.-F.; Chen, X.-L.; Fu, X.-Y.; Sun, K.; Song, X.; Qu, L.-B.; Yu, B. ACS Sustainable Chem. Eng. 2020, 8, 10740.
[4]	Tang, Z.; Pi, C.; Wu, Y.; Cui, X. Green Synth. Catal. 2024, 5, 31.
[5]	(a) Yuan, X.-Y.; Wang, C.-C.; Yu, B. Chin. Chem. Lett. 2024, 35, 109517.
	(b) Li, G.; Zhu, B.; Hu, T.; Fan, R.; Sun, W.; He, Z.; Chen, J.; Fan, B. Acta Chim. Sinica 2025, 83, 199 (in Chinese).
	(李国凯, 朱滨锋, 胡涛, 樊瑞峰, 孙蔚青, 和振秀, 陈景超, 樊保敏, 化学学报, 2025, 83, 199.)
	(c) Qi, Z.; An, Z.; Huang, B.; Wu, M.; Wu, Q.; Jiang, D. Org. Biomol. Chem. 2023, 21, 6419.
[11]	(h) Jiang, D.; Liu, F.; Yang, C.; Li, X.; Zhou, H.; Wang, H.; Qi, Z. Org. Chem. Front. 2025, 12, 5862.
[12]	Lu, Y.-H.; Mu, S.-Y.; Jiang, J.; Zhou, M.-H.; Wu, C.; Ji, H.-T.; He, W.-M. ChemSusChem 2023, 16, e202300523.
[13]	Ouyang, W.-T.; Ji, H.-T.; Jiang, J.; Wu, C.; Hou, J.-C.; Zhou, M.-H.; Lu, Y.-H.; Ou, L.-J.; He, W.-M. Chem. Commun. 2023, 59, 14029.
[14]	(a) Wen, Y.-C.; Zhu, L.-J.; Yi, R.-N.; Shen, C.; Zhu, H.-T.; Wang, Z.-L.; He, W.-M. Acta Chim. Sinica 2025, 83, 1124 (in Chinese).
	(文延萃, 朱丽君, 易荣楠, 沈超, 祝海涛, 王祖利, 何卫民, 化学学报, 2025, 83, 1124.)
	(b) Wu, Z.; Luo, W.; Ding, R.; Xin, C.; Wang, C.; He, W.-M. Chin. J. Org. Chem. 2025, 45, 3691 (in Chinese).
	(伍智林, 罗伟, 丁柔, 辛翠, 王从洋, 何卫民, 有机化学, 2025, 45, 3691.)
	(c) He, W.; Yi, R.; Yang, Z.; Wu, Z.; He, W.-M. Chin. J. Org. Chem. 2025, 45, 3534 (in Chinese).
	(何卫保, 易荣楠, 杨梓, 伍智林, 何卫民, 有机化学, 2025, 45, 3534.)
	(d) Wang, Y.-H.; He, L.-H.; Tan, Y.-Y.; Zhang, Z.-T.; Xu, Y.-D.; Ding, R.; Jiang, J.; He, W.-M. Adv. Sci. 2026, 13, e15993.
	(e) Peng, Q.-H.; Li, N.-B.; Hou, J.-C.; He, C.-J.; Yang, Y.-X.; Zhuang, C.-L.; Ou, L.-J.; Yuan, M.; He, W.-M. Chin. Chem. Lett. 2025, 36, 111402.
	(f) Hou, J.-C.; Cai, W.; Ji, H.-T.; Ou, L.-J.; He, W.-M. Chin. Chem. Lett. 2025, 36, 110469.
[5]	(d) Li, X.; Yao, H. Chin. J. Org. Chem. 2024, 44, 660.
	(e) Zhang, C.; Ding, Q.; Lv, Q.; Ma, C.; Jiang, Y.; Yi, B. Chin. J. Org. Chem. 2025, 45, 3517 (in Chinese).
	(张晨晨, 丁清杰, 吕琪妍, 马春华, 姜玉钦, 於兵, 有机化学, 2025, 45, 3517.)
	(f) Yang, W.; Zhang, Z.; Yang, Z.; Chen, X.; Qiao, L.; Chen, X.; Sun, K.; Qu, L.; Yu, B. J. Org. Chem. 2025, 90, 16403.
	(g) Jiang, D.; Yang, C.; Man, X.; Li, X.; Wang, H.; Song, Y.; Qi, Z. Org. Biomol. Chem. 2026, 24, 152.
[14]	(g) Hou, J.-C.; Ji, H.-T.; Lu, Y.-H.; Wang, J.-S.; Xu, Y.-D.; Zeng, Y.-Y.; He, W.-M. Chin. Chem. Lett. 2024, 35, 109514.

Entry	Oxidant	Solvent (V/V)	Temp./℃	Yield^b/%
1	H₂O₂	EtOH/H₂O (2/1)	80	45
2	TBHP	EtOH/H₂O (2/1)	80	83 (78)
3	DTBP	EtOH/H₂O (2/1)	80	37
4	BPO	EtOH/H₂O (2/1)	80	31
5	K₂S₂O₈	EtOH/H₂O (2/1)	80	49
6^c	TBHP	EtOH/H₂O (2/1)	80	58
7	w/o	EtOH/H₂O (2/1)	80	Trace
8	TBHP	EtOH	80	59
9	TBHP	H₂O	80	42
10	TBHP	EtOH/H₂O (3/1)	80	74
11	TBHP	EtOH/H₂O (1/1)	80	63
12	TBHP	Acetone/H₂O (2/1)	80	23
13	TBHP	DMSO/H₂O (2/1)	80	35
14	TBHP	DMF/H₂O (2/1)	80	26
15	TBHP	MeCN/H₂O (2/1)	80	39
16	TBHP	THF/H₂O (2/1)	80	Trace
17	TBHP	EtOH/H₂O (2/1)	70	63
18	TBHP	EtOH/H₂O (2/1)	r.t.	17
19	TBHP	EtOH/H₂O (2/1)	90	82

Entry	Oxidant	Solvent (V/V)	Temp./℃	Yield^b/%
1	H₂O₂	EtOH/H₂O (2/1)	80	45
2	TBHP	EtOH/H₂O (2/1)	80	83 (78)
3	DTBP	EtOH/H₂O (2/1)	80	37
4	BPO	EtOH/H₂O (2/1)	80	31
5	K₂S₂O₈	EtOH/H₂O (2/1)	80	49
6^c	TBHP	EtOH/H₂O (2/1)	80	58
7	w/o	EtOH/H₂O (2/1)	80	Trace
8	TBHP	EtOH	80	59
9	TBHP	H₂O	80	42
10	TBHP	EtOH/H₂O (3/1)	80	74
11	TBHP	EtOH/H₂O (1/1)	80	63
12	TBHP	Acetone/H₂O (2/1)	80	23
13	TBHP	DMSO/H₂O (2/1)	80	35
14	TBHP	DMF/H₂O (2/1)	80	26
15	TBHP	MeCN/H₂O (2/1)	80	39
16	TBHP	THF/H₂O (2/1)	80	Trace
17	TBHP	EtOH/H₂O (2/1)	70	63
18	TBHP	EtOH/H₂O (2/1)	r.t.	17
19	TBHP	EtOH/H₂O (2/1)	90	82

[1]	Shan Yang, Yasu Chen, Chen Zhu. Construction of N-Fused Heteroarenes via Radical-Mediated Functional Group Migration-Cyclization [J]. Chinese Journal of Organic Chemistry, 2026, 46(4): 1739-1749.
[2]	Xianting Huang, Xiaoqian Shen, Qingxu Wang, Zhongquan Liu. A Catalyst and Solvent-Free Photochemical Acylation of N-Heteroarenes with Keto Acids [J]. Chinese Journal of Organic Chemistry, 2026, 46(3): 951-960.
[3]	Yan Luo, Zhangwei Liu, Zhaolei Hu, Hongyan Bi, Dongliang Mo. Recent Advances on the Synthesis of Ten-Membered Nitrogen Heterocyclic Compounds [J]. Chinese Journal of Organic Chemistry, 2026, 46(2): 420-442.
[4]	Jiale Liu, Yucai Tang, Qiumei Yin, Jiaming Huang, Shiqiang Deng, Weiming Xia, Jie Jiang, Zu-Li Wang. Silver-Catalyzed Tandem Decarboxylative Cyclization of 2,2-Difluoro-2-(phenylthio)acetic Acids with 2-Aryl-N-acrylamide Indoles [J]. Chinese Journal of Organic Chemistry, 2026, 46(1): 118-127.
[5]	Ting Mao, Linyuan Zeng, Jilin Wen, Jia Jia. Visible Light-Mediated Iridium-Catalyzed Debromocyclization of Aliphatic α-Bromotrifluoromethyl Groups [J]. Chinese Journal of Organic Chemistry, 2025, 45(7): 2520-2528.
[6]	Xinyao Sheng, Xinxin Li, Xiao Xing, Ling Pan, Qun Liu, Yifei Li. Synthesis of α-Carbolinone Compounds Based on Tandem Cyclization Reaction of 2-Nitrochalcone and Ethyl Isocyanoacetate [J]. Chinese Journal of Organic Chemistry, 2025, 45(6): 2163-2170.
[7]	Xun Tian, Guogang Deng, Xiaodong Yang. Progress on Cobalt-Catalyzed C(sp²)—H Activation for the Construction of Nitrogen-Containing Benzo Heterocycles [J]. Chinese Journal of Organic Chemistry, 2025, 45(2): 655-667.
[8]	Chenchen Zhang, Qingjie Ding, Qiyan Lv, Chunhua Ma, Yuqin Jiang, Bing Yu. Iron-Photocatalytic Decarboxylative Functionalization Based on Ligand-to-Metal Charge Transfer [J]. Chinese Journal of Organic Chemistry, 2025, 45(10): 3517-3533.
[9]	Wenjuan Liu, Pinhong Chen. Palladium-Catalyzed Cyclization of 1,6-Enynes [J]. Chinese Journal of Organic Chemistry, 2024, 44(7): 2077-2091.
[10]	Jiwei Wu, Jun He, Jingjing Wang, Lixia Li, Caiyu Xu, Jie Zhou, Zirong Li, Huajian Xu. Electrochemical Oxidation Decarboxylative Cyclization of α-Keto Acid with o-Aminobenzylamine [J]. Chinese Journal of Organic Chemistry, 2024, 44(3): 972-980.
[11]	Hongqiong Zhao, Miao Yu, Dongxue Song, Qi Jia, Yingjie Liu, Yubin Ji, Ying Xu. Progress on Decarboxylation and Hydroxylation of Carboxylic Acids [J]. Chinese Journal of Organic Chemistry, 2024, 44(1): 70-84.
[12]	Yi Wang, Jian Zhang, Yangzi Liu, Xiaoyan Luo, Weiping Deng. Palladium-Catalyzed Asymmetric [3＋4] Cycloadditions for the Construction of Cyclohepta[b]indoles [J]. Chinese Journal of Organic Chemistry, 2023, 43(8): 2864-2877.
[13]	Jingpeng Li, Shuntao Huang, Qi Yang, Weiqiang Li, Teng Liu, Chao Huang. A Practical Synthesis of (Z)-N-Vinyl Substituted N,O-Acetals under Continuous Flow Technology [J]. Chinese Journal of Organic Chemistry, 2023, 43(4): 1550-1558.
[14]	Nan Jiang, Guanjie Huang, Yan Hu, Bo Wang. Ruthenium-Catalyzed C—H [4＋2] Annulation of Quinazolinones with Vinylene Carbonate [J]. Chinese Journal of Organic Chemistry, 2023, 43(4): 1537-1549.
[15]	Yongling Wang, Tiexin Zhang, Xuming Zhang, Hanyang Sun, Jinyao Leng, Yaming Li. Synthesis of Unnatural Amino Acid Derivatives by Visible- Light-Catalyzed Decarboxylative Alkylation of N-Aromatic Glyoxylimines [J]. Chinese Journal of Organic Chemistry, 2023, 43(12): 4284-4293.

叔丁基过氧化氢促进喹喔啉酮、N-芳基甘氨酸和多聚甲醛的三组分反应: 高效合成四氢咪唑并[1,5-a]喹喔啉酮

t-Butyl Hydroperoxide-Promoted Three-Component Reaction of Quinoxalin-2(1H)-ones, N-Phenylglycines and Paraformaldehyde: an Efficient Approach to Tetrahydroimidazo-[1,5-a]quinoxalin-4(5H)-ones

RichHTML

PDF

Supporting Info.

Knowledge

Abstract

Cite this article

share this article

Fig. & Tab. 5

References 14

Related Articles 15

Recommended Articles

Metrics

Comments