Chinese Journal of Organic Chemistry 2026, 46(4)

- About the Cover:
  
  A radical reductive dearomatization of indoles is re-ported by Yang, Li, Bai, Zhang and Shi on page 1699. Under photoredox catalysis, the reaction employs N,N-diiso- propylethylamine (DIPEA) as an organic reductant and proceeds under mild conditions. Both 2-substituted and 2-unsubstituted indoles are well tol-erated, affording a series of structurally diverse func-tionalized indoline derivatives.
- About the Cover:
  
  Four types of radical-mediated 1,2,n-trifunctionalization strategies of olefins, namely radical addition/migration/ functionalization, cycload-dition/ring-opening/migration/ functionalization, al-lylic/alkenyl sequential functionalization, and multi-functional reagent-promoted polyfunctionalization, are reviewed by Lu, Qi, Zhang, Jin, Cao and Zhang on page 1540. This review analyzes the challenges of these reactions and outlines future development directions, providing a systematic reference for the efficient syn-thesis of complex molecules and the development of green organic chemistry.
- About the Cover:
  
  Visible-light-catalyzed hydroamination, hydroami-dation, and hydrosulfonamidation of alkenes are re-viewed by Zhang, Jia, Yu, Wu, Li, and Shu on page 1166. This review summarizes recent advances in the direct coupling of readily available alkenes with various nitrogen sources under mild visible-light irradiation. Particular emphasis is focused on representative cata-lytic modes involving single-electron transfer, pro-ton-coupled electron transfer, and hydrogen atom transfer pathways, as well as their selectivity control and substrate scope.
- About the Cover:
  
  Photoredox-catalyzed dicarbofunctionalization of alky- nes has become a cutting-edge research area in organic synthesis. The latest advances in this field are reviewed by Ye, and Yuan on page 1146, with an em-phasis on substrate scope, reaction mechanisms, selec-tivity control strategies, and synthetic applications, along with a forward-looking perspective on future developments.
2026, 46(4)

25 April 2026
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REVIEWS ARTICLES HIGHLIGHTS

REVIEWS

Research Progress in Mechanically Driven Radical Reactions under Ball Milling Conditions

Yuqing Tang, Zixian Yang, Bing Yang, Yi Wang, Bingnan Du

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1111-1145 DOI: 10.6023/cjoc202512022

Abstract( 100) HTML( 8) PDF(2176KB)( 72 )

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Recent Advances in Dicarbofunctionalization of Alkynes via Photoredox Catalysis

Fu Ye, Weiming Yuan

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1146-1165 DOI: 10.6023/cjoc202512019

Abstract( 124) HTML( 10) PDF(991KB)( 103 )

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Visible-Light-Catalyzed Hydroamination, Hydroamidation and Hydrosulfonamidation of Alkenes

Haoran Zhang, Junsong Jia, Qiong Yu, Yu Wu, Yulong Li, Wei Shu

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1166-1180 DOI: 10.6023/cjoc202511015

Abstract( 200) HTML( 6) PDF(973KB)( 80 )

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Controlled Generation and Transformations of Alkene Radical Anions

Bin Zhang, Wenjing Xiao, Jiarong Chen

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1181-1204 DOI: 10.6023/cjoc202603031

Abstract( 73) HTML( 17) PDF(1217KB)( 53 )

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Recent Advances for the Synthesis of α-Alkylidene-γ-lactones

Xinran Han, Hengyu Huo, Xuepan Song, Chao Shu

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1205-1221 DOI: 10.6023/cjoc202601016

Abstract( 77) HTML( 5) PDF(876KB)( 43 )

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Recent Advances in Photocatalytic Radical-Mediated Lactone Synthesis

Ning Yu, Yuqiang Zhou, Ye Wei

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1222-1254 DOI: 10.6023/cjoc202512036

Abstract( 111) HTML( 0) PDF(1643KB)( 60 )

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Recent Progress in Sulfonyl Derivative Mediated Radical Aryl Migration

Junhua Xu, Keyuan Zhang, Chonglong He, Xin-Hua Duan, Le Liu

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1255-1283 DOI: 10.6023/cjoc202601018

Abstract( 16) HTML( 1) PDF(1280KB)( 8 )

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Hydrogen Atom Transfer-Induced Functional Group Migration

Liwei Zhao, Liang Zhang, Peng Hu

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1284-1302 DOI: 10.6023/cjoc202512041

Abstract( 24) HTML( 0) PDF(1070KB)( 10 )

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Palladium-Catalyzed Radical Reactions via Pd(I) Pathway: A Brief Summary of Reaction Patterns and Recent Progress

Yi-Fan Tan, Lei Jiao

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1303-1319 DOI: 10.6023/cjoc202512048

Abstract( 75) HTML( 1) PDF(960KB)( 59 )

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Ligand-to-Metal Charge Transfer-Driven Photoinduced Metal-Catalyzed Decarboxylative Transformation of Aryl Carboxylic Acids

Weiwen Ji, Jian Jin

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1320-1329 DOI: 10.6023/cjoc202601011

Abstract( 63) HTML( 0) PDF(953KB)( 39 )

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Recent Advances in Transition Metal-Catalyzed Radical-Mediated Selective Difunctionalization of 1,3-Dienes

Shuilin Liu, Pu Chen, Jing He, Ning Liu, Huawen Huang

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1330-1359 DOI: 10.6023/cjoc202512029

Abstract( 80) HTML( 1) PDF(1419KB)( 41 )

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Recent Advances in Photochemical Reactions Involving Elemental Sulfur (S₈)

Wenxin Su, Hao Cui, Xiao Zhang

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1360-1375 DOI: 10.6023/cjoc202512003

Abstract( 97) HTML( 0) PDF(963KB)( 65 )

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Research Progress of α-Diazo Sulfonium Salts as Free Radicals and Multivariate Reactive Species Precursors

Xing Li, Ziqiang Zhang, Zhiyuan Lin, Jiacheng Yao, Xinyan Li, Qiangqiang Li, Jun Xuan

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1376-1389 DOI: 10.6023/cjoc202512047

Abstract( 70) HTML( 0) PDF(768KB)( 72 )

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Recent Advances in Hypervalent Iodine Mediated Radical Fluoroalkylative Difunctionalization of Alkenes

Shaohua Wu, Fan Gong, Zhu Cao, Qinghai Deng

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1390-1427 DOI: 10.6023/cjoc202601040

Abstract( 65) HTML( 1) PDF(1318KB)( 36 )

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Dowd-Beckwith Reaction: From Halogen Atom Transfer to Modern Initiation Strategies

Mingqiang Li, Lei Zhou

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1428-1439 DOI: 10.6023/cjoc202512032

Abstract( 87) HTML( 1) PDF(689KB)( 78 )

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Recent Advance in Radical-Mediated Functionalization of Alkenes via Dual C—H Bond Conversion

Chen Yu, Ning Li, Qi Xue, Yang Li, Weihang Wang, Jinheng Li

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1440-1463 DOI: 10.6023/cjoc202512049

Abstract( 65) HTML( 0) PDF(1108KB)( 18 )

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Research Progress on the Functionalization of [1.1.1]Propellane via Radical Pathways

Jianyang Dong, Dong Xue

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1464-1480 DOI: 10.6023/cjoc202512007

Abstract( 131) HTML( 0) PDF(943KB)( 53 )

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Recent Advances in Enantioselective Transformations Enabled by Synergistic Photoredox/Chromium Catalysis

Yu-Chen Miao, Hang Qi, Huan-Ming Huang

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1481-1495 DOI: 10.6023/cjoc202512018

Abstract( 120) HTML( 0) PDF(873KB)( 56 )

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Research Advances on Radical Reactions in Aqueous Phase

Xiaoman Wang, Ze Wang, Jie Wu, Yi Hu, Shengqing Ye

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1496-1512 DOI: 10.6023/cjoc202512028

Abstract( 75) HTML( 0) PDF(813KB)( 44 )

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Design of Photoactive Cr- and Co-Based Complexes and Their Applications in Organic Synthesis

Lingxu Meng, Lin Shen, Xiangling Luo, Yumei Lin, Lei Gong

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1513-1528 DOI: 10.6023/cjoc202512031

Abstract( 81) HTML( 0) PDF(1006KB)( 26 )

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Radical Glycosylation of Fully Unprotected Sugars

Yujuan Wang, Feng Zhu, Bo Yang

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1529-1539 DOI: 10.6023/cjoc202512042

Abstract( 63) HTML( 0) PDF(709KB)( 30 )

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Recent Progress in Radical Mediated 1,2,n-Trifunctiona-lization of Olefins

Linyu Lu, Yutong Qi, Tinghui Zhang, Shengnan Jin, Zhongyan Cao, Hongwei Zhang

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1540-1559 DOI: 10.6023/cjoc202512033

Abstract( 96) HTML( 0) PDF(1029KB)( 62 )

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Research Progress in Radical-Mediated 1,n-Nitrogen Migration Reactions

Jiahao Chen, Beibei Zhan, Xiaheng Zhang

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1560-1571 DOI: 10.6023/cjoc202512013

Abstract( 112) HTML( 6) PDF(818KB)( 89 )

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Research Progress on the Ring-Opening Functionalization of Cyclic Sulfonium Salts

Yuqing Zhao, Xianjin Zhu, Lingyu Shi, Mingyu Wei, Zihan Xu, Yongjia Shi, Xufeng Li, Daoshan Yang

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1572-1602 DOI: 10.6023/cjoc202511018

Abstract( 74) HTML( 0) PDF(1310KB)( 33 )

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Recent Advances in Functionalization of 6-Azauracils via Radical Reactions

Jingfei Zheng, Qiyan Lv, Kai Sun, Xiaolan Chen, Lingbo Qu, Jinquan Wang, Bing Yu

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1603-1620 DOI: 10.6023/cjoc202510017

Abstract( 102) HTML( 0) PDF(3632KB)( 53 )

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Research Progress on Radical Selenosulfonylation

Shizheng Liu, Mingyu Dou, Yu Cui, Jianmin Dou, Wenting Wei

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1621-1634 DOI: 10.6023/cjoc202510020

Abstract( 90) HTML( 0) PDF(914KB)( 27 )

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Recent Advances in Sulfoxide Synthesis via Sulfinyl Building Blocks

Zhenlei Zou, Yifan Li, Chen Chen, Wangzhe Chen, Weigang Zhang, Yi Wang

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1635-1658 DOI: 10.6023/cjoc202510008

Abstract( 167) HTML( 0) PDF(3389KB)( 54 )

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ARTICLES

Electrochemically Driven Radical Alkylation of Alkenes with 1,3-Dicarbonyl Compounds

Yong Liu, Juan Li, Lingfan Wang, Baotong Huang, Lingzi Peng, Jin Song, Chang Guo

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1659-1667 DOI: 10.6023/cjoc202601014

Abstract( 68) HTML( 0) PDF(662KB)( 27 )

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t-Butyl Hydroperoxide-Promoted Three-Component Reaction of Quinoxalin-2(1H)-ones, N-Phenylglycines and Paraformaldehyde: an Efficient Approach to Tetrahydroimidazo-[1,5-a]quinoxalin-4(5H)-ones

Ting Li, Wentao Ouyang, Rongnan Yi, Yucai Tang, Zi Yang, Chao Wu, Weimin He

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1668-1676 DOI: 10.6023/cjoc202601030

Abstract( 62) HTML( 1) PDF(754KB)( 20 )

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Visible-Light Induced Hydrophosphination of Olefins

Ziliang Yuan, Bingdong Li, Dinghai Wang

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1677-1684 DOI: 10.6023/cjoc202512046

Abstract( 66) HTML( 0) PDF(483KB)( 36 )

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Visible-Light Induced Copper-Catalyzed C—C Bond Cleavage/Coupling of Spiro Dihydroquinazolinones with Isatins: a Synthetic Method to 3-Alkyl-3-hydroxy-2-oxindoles

Xin Chen, Shutao Wang, Wen-Peng Yang, Chuyang Wang, Xin-Hua Duan, Li-Na Guo

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1685-1698 DOI: 10.6023/cjoc202601003

Abstract( 63) HTML( 6) PDF(1555KB)( 37 )

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Visible-Light Photoredox-Catalyzed Reductive Dearomatization of Indoles

Dan Yang, Tianzhen Li, Jingyi Bai, Honghao Zhang, Feng Shi

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1699-1712 DOI: 10.6023/cjoc202512044

Abstract( 78) HTML( 0) PDF(1094KB)( 44 )

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Aerobic Photocatalytic N-Demethylation of Amides Enabled by a Hydrochloric Acid-Dimethyl Sulfoxide System

Qiong Liu, Xiulong Yang, Haoyuan Li, Jiahui Shen, Shuo Yang, Qingyuan Meng, Xiaoying Niu

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1713-1721 DOI: 10.6023/cjoc202512011

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Trifluoromethyl Radical-Mediated C(sp³)—H Alkylation Enabled by Photoinduced Thioxanthone Catalysis

Dongsheng Li, Haowen Zheng, Hongping Deng

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1722-1729 DOI: 10.6023/cjoc202512043

Abstract( 74) HTML( 1) PDF(593KB)( 48 )

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Visible-Light-Induced Aerobic Dehydrogenative Couplings of Quinoxalin-2(1H)-ones with Aldehydes

Yixi Zhang, Lijuan Pang, Huawen Huang

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1730-1738 DOI: 10.6023/cjoc202512050

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Construction of N-Fused Heteroarenes via Radical-Mediated Functional Group Migration-Cyclization

Shan Yang, Yasu Chen, Chen Zhu

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1739-1749 DOI: 10.6023/cjoc202512005

Abstract( 79) HTML( 0) PDF(617KB)( 28 )

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Metal-Free Selective Chlorination of Polyenes

Qixiang Wang, Shengxi Chen, Jing Wang, Dong Chen, Xiaoguang Bao, Xinxin Wu

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1750-1762 DOI: 10.6023/cjoc202510009

Abstract( 117) HTML( 5) PDF(688KB)( 32 )

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Visible Light-Driven Tandem Cyclization Reactions of 1,3-Eneynes with 4-Acyl-dihydropyridines to Access Azaarene-Functionalized Polysubstituted Furans

Guanghui Wang, Binghui Wang, Xu Ban, Xiaowei Zhao, Zhiyong Jiang

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1763-1775 DOI: 10.6023/cjoc202509014

Abstract( 114) HTML( 0) PDF(576KB)( 39 )

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Visible-Light-Induced Phosphorylation Cyclization to Phosphorylated Indole-Fused Diazepines

Xinyi Hou, Tongtong Shi, Zejiang Li, Qinghao Dong, Kai Sun, Xin Wang

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1776-1787 DOI: 10.6023/cjoc202509032

Abstract( 156) HTML( 0) PDF(665KB)( 62 )

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HIGHLIGHTS

Regio- and Enantioselective Intermolecular Carbo-halogenation of Alkenes via Nickel/N-Heterocyclic Carbene Catalysis

Yu Zou, Jun Wang

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1788-1790 DOI: 10.6023/cjoc202600006

Abstract( 16) HTML( 0) PDF(406KB)( 4 )

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Photodriven Enantioselective 6-endo Hydroaminative Cyclization to Chiral 4-Substituted 3,4-Dihydroisoquinolones

Lingyu Shi, Daoshan Yang

Chinese Journal of Organic Chemistry 2026, 46 (4), pp 1791-1793 DOI: 10.6023/cjoc202600007

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