Research on Secondary Metabolites from a Mangrove-Derived Fungus Penicillium janthinellum XLN32122 and Their Biological Activities

doi:10.6023/cjoc202506026

Chinese Journal of Organic Chemistry ›› 2026, Vol. 46 ›› Issue (2): 678-683.DOI: 10.6023/cjoc202506026 Previous Articles Next Articles

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1株红树来源真菌Penicillium janthinellum XLN32122次级代谢产物与生物活性研究

石珏莹^a^,^b, 仇毅康^a^,^b, 兰晶^a^,^b, 徐振洋^a^,^b, 王熠^a^,^b, 李嘉祥^a^,^b, 罗由萍^a^,^b, 黄国雷^a^,^b^,^*(), 郑彩娟^a^,^b^,^*()

^a 海南师范大学热带药用资源化学教育部重点实验室海口 571158
^b 海南师范大学化学与化工学院热带药用植物化学海南省重点实验室海口 571158

收稿日期:2025-06-18 修回日期:2025-09-18 发布日期:2025-10-29
通讯作者: 黄国雷, 郑彩娟
基金资助:
国家自然科学基金(32160108); 海南省重点研发计划(ZDYF2024SHFZ116); 海南省院士创新平台专项(YSPTZX202309); 海南省高等学校科学研究项目(Hnky2022ZD-6); 海南师范大学大学生创新训练(202411658006)

Research on Secondary Metabolites from a Mangrove-Derived Fungus Penicillium janthinellum XLN32122 and Their Biological Activities

Jueying Shi^a^,^b, Yikang Qiu^a^,^b, Jing Lan^a^,^b, Zhenyang Xu^a^,^b, Yi Wang^a^,^b, Jiaxiang Li^a^,^b, Youping Luo^a^,^b, Guolei Huang^a^,^b^,^*(), Caijuan Zheng^a^,^b^,^*()

^a Key Laboratory of Tropical Medicinal Resources Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158
^b Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158

Received:2025-06-18 Revised:2025-09-18 Published:2025-10-29
Contact: Guolei Huang, Caijuan Zheng
Supported by:
National Natural Science Foundation of China(32160108); Science and Technology Special Fund of Hainan Province(ZDYF2024SHFZ116); Specific Research Fund of the Innovation Center for Academicians of Hainan Province(YSPTZX202309); Scientific Research Project of Hainan Higher Education Institutions(Hnky2022ZD-6); Hainan Normal University National College Student Innovation Training Program(202411658006)

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Abstract

A new heterocyclic dipeptide with a highly functionalized 1,2-oxazadecaline core, named trichodermamide H (1), and three known analogues, along with three known polyketides, were isolated from the fermentation extract of the mangrove- derived fungus Penicillium janthinellum XLN32122. The structure of 1 was elucidated on the basis of extensive 1D and 2D NMR spectra data analysis, HR-ESI-MS, electronic circular dichroism (ECD) calculations. Trichodermamide B (3) exhibited better inhibitory effect on nitric oxide (NO) production in lipopolysaccharide (LPS) induced RAW 264.7 cells with an IC₅₀ value of (13.13±0.005) μmol/L than that of the positive control dexamethasone [IC₅₀=(136.84±1.33) μmol/L]. Compound 3 exhibited antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) with an IC₅₀ value of 12.5 μg/mL, while the positive control vancomycin showed an IC₅₀ value of 1.563 μg/mL.

Key words: mangrove-derived fungi, secondary metabolites, anti-inflammatory activity, antibacterial activity

Cite this article

Jueying Shi, Yikang Qiu, Jing Lan, Zhenyang Xu, Yi Wang, Jiaxiang Li, Youping Luo, Guolei Huang, Caijuan Zheng. Research on Secondary Metabolites from a Mangrove-Derived Fungus Penicillium janthinellum XLN32122 and Their Biological Activities[J]. Chinese Journal of Organic Chemistry, 2026, 46(2): 678-683.

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Position	δ_C	δ_H (J in Hz)
1	160.9 (C)	—
2	149.9 (C)	—
3	26.3 (CH₂)	2.07 (d, 18.8), 2.28 (dd, 18.8, 2.4)
4	63.9 (C)	—
4-OH	—	5.09 (s)
5	69.4 (CH)	3.82 (br d, 4.8)
5-OH	—	5.31 (d, 4.8)
6	127.4 (CH)	5.69 (ddd, 10.4, 4.8, 2.4)
7	130.5 (CH)	5.48 (dd, 10.4, 2.4)
8	66.4 (CH)	3.97 (t, 7.6)
8-OH	—	5.46 (d, 6.4)
9	81.7 (CH)	4.11 (dd, 7.6, 2.0)
1'	157.9 (C)	—
2'	121.0 (C)	—
3'	123.9 (CH)	8.53 (s)
4'	113.7 (C)	—
5'	123.1 (CH)	7.49 (d, 8.8)
6'	110.2 (CH)	7.13 (d, 8.8)
7'	153.9 (C)	—
8'	135.3 (C)	—
9'	143.6 (C)	—
10'	56.5 (OMe)	3.89 (s)
11'	60.9 (OMe)	3.83 (s)
NH	—	9.32 (s)

Position	δ_C	δ_H (J in Hz)
1	160.9 (C)	—
2	149.9 (C)	—
3	26.3 (CH₂)	2.07 (d, 18.8), 2.28 (dd, 18.8, 2.4)
4	63.9 (C)	—
4-OH	—	5.09 (s)
5	69.4 (CH)	3.82 (br d, 4.8)
5-OH	—	5.31 (d, 4.8)
6	127.4 (CH)	5.69 (ddd, 10.4, 4.8, 2.4)
7	130.5 (CH)	5.48 (dd, 10.4, 2.4)
8	66.4 (CH)	3.97 (t, 7.6)
8-OH	—	5.46 (d, 6.4)
9	81.7 (CH)	4.11 (dd, 7.6, 2.0)
1'	157.9 (C)	—
2'	121.0 (C)	—
3'	123.9 (CH)	8.53 (s)
4'	113.7 (C)	—
5'	123.1 (CH)	7.49 (d, 8.8)
6'	110.2 (CH)	7.13 (d, 8.8)
7'	153.9 (C)	—
8'	135.3 (C)	—
9'	143.6 (C)	—
10'	56.5 (OMe)	3.89 (s)
11'	60.9 (OMe)	3.83 (s)
NH	—	9.32 (s)

1株红树来源真菌Penicillium janthinellum XLN32122次级代谢产物与生物活性研究

Research on Secondary Metabolites from a Mangrove-Derived Fungus Penicillium janthinellum XLN32122 and Their Biological Activities

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