Alkylation in solid-liquid two phase systems III:alkylation of ethyl acetoacetate

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Chin. J. Org. Chem. ›› 1987, Vol. 7 ›› Issue (1): 56-59. Previous Articles Next Articles

固-液相烃化反应的研究III:乙酰乙酯的烃化反应

徐泽奇;徐成治

上海医科大学药学院有机化学教研室

发布日期:1987-02-25

Alkylation in solid-liquid two phase systems III:alkylation of ethyl acetoacetate

XU ZEQI;XU CHENGZHI

Published:1987-02-25

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Abstract

Et acetoacetate (I) was alkylated with RX (R = Me, Et, Pr, Me2CH, Bu, sec-Bu, Me3C, n-amyl, allyl, PhCH2; X = iodo, Br, Cl) and K2CO3 in the absence of solvent and catalyst. Thus, heating I with EtBr and K2CO3 at 110?for 4.5 h gave 73.4% MeCOCHEtCO2Et and Me(OEt):CHCO2Et.

Key words: REACTION MECHANISM, TEMPERATURE, CARBONATE, LIQUID PHASE, ETHYL ESTER, OXOBUTANOIC ACID P, ALKYLATION, REACTION RATE, SOLID PHASE REACTION, GROUP IA COMPOUNDS

CLC Number:

O621

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XU ZEQI;XU CHENGZHI. Alkylation in solid-liquid two phase systems III:alkylation of ethyl acetoacetate[J]. Chin. J. Org. Chem., 1987, 7(1): 56-59.

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固-液相烃化反应的研究III:乙酰乙酯的烃化反应

Alkylation in solid-liquid two phase systems III:alkylation of ethyl acetoacetate

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