Studies of nucleophilic displacements of nicleophilic agent of nitrogen on 2-methylsulphonyl-5-(3,4,5- trimethoxyphenyl)-1,3,4-oxadiazole

Abstract

In this paper, 2-methylsulphonyl-5-(3,4,5-trimethoxyl- phenyl)-1,3,4-oxadiazole have been prepared and their subsequent transformations with a variety of nucleophilic reagents have been studied. Whereas the 2-methylsulphonyl- 5-(3,4,5-trimethoxylphenyl)-1,3,4-oxadiazole derivatives have been obtained from 2-mercupto-5-(3,4,5-trimethoxylphenyl)- 1,3,4-oxadiazole through methylation and subsequent oxidation with KMnO~4. Their structural proofs were based on elemental, IR, ^1H NMR, and MS analyses. The compounds 4 (2.0×10^-^4 mol·L^-^1) were preliminary screened for antibacterial activity against Bacillus Substilis and Escherichia Coli.

Key words: TETRAZOLE P, HYDRAZIDE, NUCLEOPHILIC REAGENTS

CLC Number:

O621

Cite this article

FENG XIAOMING;CHEN RONG;LIN TAO. Studies of nucleophilic displacements of nicleophilic agent of nitrogen on 2-methylsulphonyl-5-(3,4,5- trimethoxyphenyl)-1,3,4-oxadiazole[J]. Chin. J. Org. Chem., 1994, 14(3): 293-299.

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含氮亲核试剂在2-甲磺酰基-5-(3,4,5-三甲氧基苯基)-1,3,4-恶二唑环上取代反应的研究