Chin. J. Org. Chem. ›› 1994, Vol. 14 ›› Issue (6): 626-629. Previous Articles     Next Articles

Original Articles

2-苯氧(硫)甲基-6,7-亚甲二氧-3-喹啉酸乙酯及其衍生物的合成

杨定乔;高永俊;姜贵吉   

  1. 黄冈师范专科学校化学系;延边大学化学系
  • 发布日期:1994-12-25

Synthesis of ethyl 2-phenoxy (thio) methyl-6,7- methylenedioxy-3-quinolinecarboxylate and its derivatives

YANG DINGQIAO;GAO YONGJUN;JIANG GUIJI   

  • Published:1994-12-25

The Base-Catalyzed Condensation of 6-aminopiperonal with ethyl acetoacetate followed by bromination with NBS gave ethyl 2-bromomethyl-6,7-methylenedioxy-3- quinolinecarboxylate (2). Williamson reaction of 2 with un- and substituted phenol or thiothenol yielded ethyl 2-(un) substituted phenoxy (thioxy) methyl-6,7- methylenedioxy-3-quinolinecarboxylate (3a~g) in excellent yields Electron-withdrawing group at the phenol or thiothenol ring was favorable for the formation of the nucleophile and williamson reaction.

Key words: SUBSTITUTION REACTION, QUINOLINE P, CONDENSATION REACTION

CLC Number: