Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (10): 3262-3278.DOI: 10.6023/cjoc202005008 Previous Articles     Next Articles

Special Issue: 黄乃正院士七十华诞专辑


田飞, 张键, 杨武林, 邓卫平   

  1. 华东理工大学药学院 上海市新药设计重点实验室 上海 200237
  • 收稿日期:2020-05-04 修回日期:2020-05-23 发布日期:2020-06-01
  • 通讯作者: 杨武林, 邓卫平;
  • 基金资助:

Progress in Iridium-Catalyzed Asymmetric Allylic Substitution Reactions via Synergetic Catalysis

Tian Fei, Zhang Jian, Yang Wulin, Deng Weiping   

  1. School of Pharmacy and Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology, Shanghai 200237
  • Received:2020-05-04 Revised:2020-05-23 Published:2020-06-01
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 21772038, 21901072), the Fundamental Research Funds for the Central Universities (No. 222201814048) and the Shanghai Sailing Program (No. 18YF140560).

Iridium-catalyzed asymmetric allylic substitution reaction has become one of the most important methods for the synthesis of chiral compounds due to its exceptional branched regioselectivity and excellent enantioselectivity. The scope of nucleophiles will be further expanded by synergetic catalysis system of iridium and other catalysts (organocatalysts, other transition metal catalysts). Besides, it is possible to improve the enantioselectivity of the reaction and even realize the stereodivergent synthesis of the products with multiple stereocenters. The progress in the field of catalytic asymmetric allylic substitutions through synergetic iridium and organocatalysis or other transition metal catalysis is summarized. These reactions are classified according to the types of catalysts (aminocatalyst, phase transfer catalyst, Brønsted acid, Lewis base, transition metal). Meanwhile, the mechanism of representative reactions, the existing problems and the prospects in this area are briefly described.

Key words: asymmetric catalysis, allylic substitution reaction, iridium catalyst, synergetic catalysis