(4S, 5R)-Sitophilure, the major component of the aggregation pheromone of the rice weevil and the maize weevil, was stereoselectively synthesized by six-step sequence starting from N-bornane-2, 10-sultam(2), the two asymmetric carbon atoms of the target product was achieved by employing asymmeric syn-aldolization of N-propionyl bornane-2, 10-sultam(3) with propylaldehyde. The enantiomeric excess of (4S, 5R)-Sitophilure prepared by this route is about 96%.

Key words: BORNANE, PHEROMONE, STEREOSELECTIVITY