Chin. J. Org. Chem. ›› 1999, Vol. 19 ›› Issue (1): 59-62. Previous Articles     Next Articles

Original Articles

用(R)-(+)-缩水甘油的亲核开环反应制备手性连二醇

张生勇;戴寿荣;孙晓莉;王建华   

  1. 第四军医大学化学教研室.;西北大学化学系.西安(710069)
  • 发布日期:1999-02-25

Synthesis of chiral nonracemic vicinal diols via nucleophilic ring- opening of (R)-(+)-glycidol

Zhang Shengyong;Dai Shourong;Sun Xiaoli;Wang Jianhua   

  1. Univ of No.4 Military Medicine, Teach Lab of Chem.;Northwest Univ, Dept Chem.Xian(710069)
  • Published:1999-02-25

(R)-(+)-Glycidol 1 was synthesized from D-mannitol. Nucleophilic ring-opening of this epoxide gave a convenient method for generation a variety of chiral nonracemic vicinal diols in high stereoselectivity (93%-96% e.e.).

Key words: NUCLEOPHILIC REACTION, SELECTIVITY, MANNITOL, RING CLEAVAGE REACTION, DIHYDRIC ALCOHOL, EPIHYDRIC ALOCOHOL (=EPIHYDRIN ALCOHOL)

CLC Number: