Synthesis and characterization of  chlorodiphenylgermanium dithiocarbamates

Abstract

Thirteen chlorodiphenylgermanium dithiocarbamates Ph2GeCl(S2CNRR') were synthesized by the reaction of corresponding diphenylgermanium dichloride with dithiocarbamates in 1:1 stoichiometry. Their structure were confirmed by elemental analysis,IR,1^H NMR and MS. These results revealed that the dithiocarbamate ligands were coordinated to Ge in an anisobidentate fashion. Preliminary study of their biological activity showed that some of them had better antitumour activity in vitro.

Key words: ORGANO GERMANIUM, BIOLOGICAL ACTIVITY, SYNTHESIS METHODS, STRUCTURE CHARACTERISTICS

CLC Number:

O627

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Yin Handong;Zhang Rufen;Wang Yong;Ma Chunlin;Lei Fengqin. Synthesis and characterization of chlorodiphenylgermanium dithiocarbamates[J]. Chin. J. Org. Chem., 2001, 21(8): 589-592.

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氯代二苯基锗氨荒酸酯的合成及表征

Synthesis and characterization of chlorodiphenylgermanium dithiocarbamates

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