Solid-Phase Synthesis of 3,4-Diamino-1H-pyrazolo[5,4-d]pyrimidines

Chinese Journal of Organic Chemistry ›› 2004, Vol. 24 ›› Issue (11): 1436-1439. Previous Articles Next Articles

3,4-二胺-1H-吡唑并[5,4-d]嘧啶的固相合成

谢君, 马月龙, 肖元晶, 杨苹^*

华东师范大学化学系上海 200062

收稿日期:2003-10-27 修回日期:2004-04-14 接受日期:2004-05-14 发布日期:2022-09-21
通讯作者: ^* E-mail: yanglp@china.com; Fax: 62232487.

Solid-Phase Synthesis of 3,4-Diamino-1H-pyrazolo[5,4-d]pyrimidines

XIE Jun, MA Yue-Long, XIAO Yuan-Jing, YANG Li-Ping^*

Department of Chemistry, East China Normal University, Shanghai 200062

Received:2003-10-27 Revised:2004-04-14 Accepted:2004-05-14 Published:2022-09-21

Abstract

An efficient method for the solid-phase synthesis of varioussubstituted pyrazolo[5,4-d]pyrimidine (8) was described. Merrifield resin was used as a starting material to react with compound 3 giving resin 4. The resin 4 was followed by reductive amination, substitution, intramolecular nucleophilic addition to afford resin 7. Cleavage from the resin using trifluroactic acid gave the desired 3,4-diamino-1H-pyrazolo [5,4-d]pyrimidines.

Key words: solid-phase synthesis, pyrazolo[5,4-d]pyrimidine, resin, linker

Cite this article

XIE Jun, MA Yue-Long, XIAO Yuan-Jing, YANG Li-Ping. Solid-Phase Synthesis of 3,4-Diamino-1H-pyrazolo[5,4-d]pyrimidines[J]. Chinese Journal of Organic Chemistry, 2004, 24(11): 1436-1439.

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3,4-二胺-1H-吡唑并[5,4-d]嘧啶的固相合成

Solid-Phase Synthesis of 3,4-Diamino-1H-pyrazolo[5,4-d]pyrimidines

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