Four new ribavirin derivatives were synthesized. Tetra-acetylribofuranose reacts with 1,2,4-triazole-3-carboxylate through condensation, ammonolysis, protection, nucleophilic substitution and hydrolysis to give target compounds4a～4d. Some experimental parameters were discussed. Chemical structures of these four new compounds have been confirmed bymeans of ¹H NMR, MS spectra and elemental analysis. The resultsof bioactivity in vivo of these target compounds showed that two of the fournew 5'-substituted ribavirin analogs have anti-influenza A activities to some extent.

Key words: tetra-acetylribofuranose, 1,2,4-triazole-3-carboxylate, ribavirin and derivative, synthesis, antiviral