Synthesis and Insecticidal Activities of Novel Polyhalo Benzoyl-phenylurea Derivatives

Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (03): 304-307. Previous Articles Next Articles

Original Articles

多卤代苯甲酰基脲类几丁质抑制剂的合成及杀虫活性多卤代苯甲酰基脲类几丁质抑制剂的合成及杀虫活性

林军*^,1,2，严胜骄¹,2，杨丽娟¹,2，李俊峰¹，刘复初¹

(¹云南大学应用化学系云南大学生物制药创新人才培养基地昆明 650091)
(²南开大学元素有机化学研究所元素有机化学国家重点实验室天津 300071)

收稿日期:2004-03-12 修回日期:2004-09-23 发布日期:2005-02-28
通讯作者: 林军

Synthesis and Insecticidal Activities of Novel Polyhalo Benzoyl-phenylurea Derivatives

LIN Jun*^,1,2,YAN Sheng-Jiao¹,2,YANG Li-Juan¹,2,LI Jun-Feng¹,LIU Fu-Chu¹

(¹ Department of Applied Chemistry, Center for Advanced Studies of Medicinal and Organic Chemis-try,
Yunnan University, Kunming 650091)
(²State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071)

Received:2004-03-12 Revised:2004-09-23 Published:2005-02-28
Contact: LIN Jun

Abstract

Ten novel polyhalo benzoylphenylurea chitin inhibitor derivatives have been synthesized in over 30%～50% yields from readily available starting material chlorothalonil 1 via fluorine exchange, aminolysis, decarboxylation and acylation reactions. All products were characterized by ¹H NMR, HREIMS and IR spectra. Preliminary bioactive research showed that some of the synthesized compounds have the potential insecticidal activities against Mythimna separata and Culex pipiens pallens.

Key words: chitin inhibitor, insecticidal activity, benzoylphenylurea, chlorothalonil

Cite this article

LIN Jun*^,1,2,YAN Sheng-Jiao^1,2,YANG Li-Juan^1,2,LI Jun-Feng,LIU Fu-Chu. Synthesis and Insecticidal Activities of Novel Polyhalo Benzoyl-phenylurea Derivatives[J]. Chin. J. Org. Chem., 2005, 25(03): 304-307.

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多卤代苯甲酰基脲类几丁质抑制剂的合成及杀虫活性多卤代苯甲酰基脲类几丁质抑制剂的合成及杀虫活性

Synthesis and Insecticidal Activities of Novel Polyhalo Benzoyl-phenylurea Derivatives

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