Novel Solid-phase Synthetic Method of Sansalvamide A

Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (05): 604-607. Previous Articles Next Articles

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Sansalvamide A固相合成新方法

刘守信*^,1,2，冯霄¹，耿艳楼²，姚军²，李军章²

(¹西安交通大学环境与化学工程学院西安 710049)
(²河北科技大学化学与制药工程学院石家庄 050018)

收稿日期:2004-07-12 修回日期:2005-03-21 发布日期:2004-04-30
通讯作者: 刘守信

Novel Solid-phase Synthetic Method of Sansalvamide A

LIU Shou-Xin*^,1,2,FENG Xiao¹,GENG Yan-Lou²,YAO Jun²,LI Jun-Zhang²

(¹College of Environment and Chemical Engineering, Xi'an Jiaotong University, Xi'an 710049)
(²College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018)

Received:2004-07-12 Revised:2005-03-21 Published:2004-04-30
Contact: LIU Shou-Xin

Abstract

It was reported that butyldiethylsilane polystyrene reacted with N-Boc-4-bromophenylalanine under palladium catalyzation to directly form silicon-linker with silicon aryl carbon bond. The peptide chain was elongated by using Boc strategy. And sansalvamide A was obtained by solid phase synthesis using PyBOP (benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluoro- phosphate) as cyclization reagent.

Key words: silicon-linker, sansalvamide A, palladium catalyst, cyclic peptide, solid phase synthesis

Cite this article

LIU Shou-Xin*^,1,2,FENG Xiao,GENG Yan-Lou²,YAO Jun²,LI Jun-Zhang². Novel Solid-phase Synthetic Method of Sansalvamide A[J]. Chin. J. Org. Chem., 2005, 25(05): 604-607.

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Sansalvamide A固相合成新方法

Novel Solid-phase Synthetic Method of Sansalvamide A

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