Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (06): 629-633. Previous Articles     Next Articles

Review

醇脱氢酶结构和作用机理研究进展

许松伟,姜忠义*,吴洪   

  1. (天津大学化工学院 天津 300072)
  • 收稿日期:2004-05-24 修回日期:2004-11-18 发布日期:2005-05-30
  • 通讯作者: 姜忠义

Progress in Structure and Kinetic Mechanism of Alcohol Dehydro-genase

XU Song-Wei, JIANG Zhong-Yi*, WU Hong   

  1. (School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072)
  • Received:2004-05-24 Revised:2004-11-18 Published:2005-05-30

The type of alcohol dehydrogenases, the chemical and physical properties and structure of active site of two common types of alcohol dehydrogenase, yeast alcohol dehydrogenase (YADH) and liver alcohol dehydrogenase (LADH) were introduced. Research progress in the kinetic mechanism of YADH and LADH was summarized with special focus on the progress in the proton transfer and hydride transfer, two key steps involved in the dehydrogenase-catalyzed reaction.

Key words: hydride, nicotinamide adenine dinucleotide, proton, mechanism, alcohol dehydrogenase