Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (02): 219-222. Previous Articles     Next Articles

Original Articles

2-氰基-2,3,3-三甲基-5-硫代-吡咯烷的合成新法

胡炳成*,吕春绪,蔡超君   

  1. (南京理工大学化工学院 南京 210094)
  • 收稿日期:2005-04-04 修回日期:2005-08-29 发布日期:2006-01-21
  • 通讯作者: 胡炳成

A Novel Method for Synthesis of 2-Cyano-2,3,3-trimethyl-5- thi-oxopyrrolidine

HU Bing-Cheng*,LÜ Chun-Xu,CAI Chao-Jun   

  1. (School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 210094)
  • Received:2005-04-04 Revised:2005-08-29 Published:2006-01-21
  • Contact: HU Bing-Cheng

2-Cyano-2,3,3-trimethyl-5-thioxopyrrolidine was efficiently synthesized in a total yield of 37% from methyl 3,3-dimethyl-4-pentenate via six steps, including an intramolecular cyclization and an elimination of hydrogen iodide as key steps. All compounds were characterized by elemental analysis, 1H NMR, IR and MS spectra.

Key words: methyl dimethylpentenate, cyclization, elimination, cyanotrimethyl thioxopyrrolidine