Microwave Assisted One-Pot Synthesis of Carbamate-Type Molecular Tweezers Based on α-Hyodeoxycholic Acid

Chin. J. Org. Chem. ›› 2007, Vol. 27 ›› Issue (06): 772-777. Previous Articles Next Articles

Original Articles

微波促进一锅法合成氨基甲酸酯型α-猪去氧胆酸分子钳

刘兴利^a，赵志刚*^,a，陈淑华^b

(^a西南民族大学化学与环境保护工程学院成都 610041)
(^b四川大学化学学院成都 610064)

收稿日期:2006-11-21 修回日期:2007-03-28 发布日期:2007-05-21
通讯作者: 赵志刚

Microwave Assisted One-Pot Synthesis of Carbamate-Type Molecular Tweezers Based on α-Hyodeoxycholic Acid

LIU Xing-Li^a, ZHAO Zhi-Gang*^,a, CHEN Shu-Hua^b

(^aCollege of Chemistry and Environmental Protection Engineering, Southwest University for Nation-alities, Chengdu 610041)
(^bFaculty of Chemistry, Sichuan University, Chengdu 610064)

Received:2006-11-21 Revised:2007-03-28 Published:2007-05-21
Contact: ZHAO Zhi-Gang

Abstract

A series of new chiral molecular tweezers were synthesized in excellent yields by using α-hyodeoxycholic acid as spacer to bridge different aromatic amines via triphosgene under mi-crowave irradiation. Their structures were characterized by ¹H NMR, IR, MS spectra and ele-mental analysis. The recognition properties of these molecular tweezers for neutral molecules and D/L-amino acid methyl esters were investigated. The results indicate that these molecular tweezers not only recognize neutral organic molecules but also have good enantioselectivity for D/L-methyl esters of amino acids.

Key words: one-pot synthesis, α-hyodeoxycholic acid, molecular tweezer, microwave irradiation

Cite this article

LIU Xing-Li^a, ZHAO Zhi-Gang*^,a, CHEN Shu-Hua^b. Microwave Assisted One-Pot Synthesis of Carbamate-Type Molecular Tweezers Based on α-Hyodeoxycholic Acid[J]. Chin. J. Org. Chem., 2007, 27(06): 772-777.

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微波促进一锅法合成氨基甲酸酯型α-猪去氧胆酸分子钳

Microwave Assisted One-Pot Synthesis of Carbamate-Type Molecular Tweezers Based on α-Hyodeoxycholic Acid

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