Study on X-ray Crystallography and Antimycobacterial Bioactivity of the Stereoisomer of Hirsutellide A

Chin. J. Org. Chem. ›› 2007, Vol. 27 ›› Issue (11): 1366-1368. Previous Articles Next Articles

Original Articles

Hirsutellide A立体异构体的单晶结构与抗分支杆菌生物活性研究

许艳杰^a，李江胜^b，颜范勇^b，陈立功*^,a

(^a天津大学化工学院天津 300072)
(^b天津大学药物科学与技术学院天津 300072)

收稿日期:2007-01-24 修回日期:2007-03-23 发布日期:2007-10-20
通讯作者: 陈立功

Study on X-ray Crystallography and Antimycobacterial Bioactivity of the Stereoisomer of Hirsutellide A

XU Yan-Jie^a,LI Jiang-Sheng^b,YAN Fan-Yong^b,CHEN Li-Gong*^,a

(^aSchool of Chemical Engineering and Technology, Tianjin University, Tianjin 300072)
(^bSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072)

Received:2007-01-24 Revised:2007-03-23 Published:2007-10-20
Contact: CHEN Li-Gong

Abstract

X-ray crystallography and antimycobacterial activity of a cyclohexadepsipeptide, one of the stereoisomers of hirsutellide A, were studied. Its single crystal structure reveals that the 18 membered macrocycle has a distorted saddle shape. The cyclopeptide exhibited no significant antimycobacterial activity in vitro. It was concluded that the chiral center of 3'-C was one of the pivotal factor in hirsutellide A for its biological activity.

Key words: single crystal structure, biological activity, cyclohexadepsipeptide, antimycobacterial, hirsutellide A

Cite this article

XU Yan-Jie^a,LI Jiang-Sheng^b,YAN Fan-Yong^b,CHEN Li-Gong*^,a. Study on X-ray Crystallography and Antimycobacterial Bioactivity of the Stereoisomer of Hirsutellide A[J]. Chin. J. Org. Chem., 2007, 27(11): 1366-1368.

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Hirsutellide A立体异构体的单晶结构与抗分支杆菌生物活性研究

Study on X-ray Crystallography and Antimycobacterial Bioactivity of the Stereoisomer of Hirsutellide A

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