Syntheses of 2-(p-Aminophenyl)-6-substituent-benzothiazoles

Abstract

A series of novel 2-(p-aminophenyl)-6-substituent-benzothiazole derivatives as potential β-amyloid PET (positron emission tomography) tracers were prepared from proper 2-amino-6-substituted benzothiazoles through basic hydrolysis, intermolecular cycloaddition and N/O-alkylation reactions. Their structures were confirmed by IR, ¹H NMR, EI/ESI-MS, HRMS spectra and elemental analysis. The sequence of binding affinities of some compounds with human brain homogenate was analyzed.

Key words: β-amyloid, synthesis, bind-ing affinity, characterization, 2-(p-aminophenyl)-6-substituent-benzothiazole

Cite this article

ZHENG Ming-Qiang,b,YIN Duan-Zhi*^,a,SHEN YU-Mei^a,LI Gu-Cai^a. Syntheses of 2-(p-Aminophenyl)-6-substituent-benzothiazoles[J]. Chin. J. Org. Chem., 2007, 27(11): 1369-1373.

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