Condensation Reactions of Aromatic Aldehydes with 3-Methyl-4,5- dihydroisoxazol-5-one without Solvent and Catalyst

Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (05): 914-917. Previous Articles Next Articles

Reports

无溶剂无催化剂条件下芳香醛与3-甲基异噁唑-5-酮的缩合反应

张英群^*，王春，张美月，崔朋雷，李越敏
周欣，李敬慈

(河北农业大学理学院保定 071001)

收稿日期:2007-09-30 修回日期:2007-10-19 发布日期:2008-05-20
通讯作者: 张英群

Condensation Reactions of Aromatic Aldehydes with 3-Methyl-4,5- dihydroisoxazol-5-one without Solvent and Catalyst

ZHANG Ying-Qun*,WANG Chun,ZHANG Mei-Yue,CUI Peng-Lei
LI Yue-Min,ZHOU Xin,LI Jing-Ci

(College of Science, Agricultural University of Hebei, Baoding 071001)

Received:2007-09-30 Revised:2007-10-19 Published:2008-05-20
Contact: ZHANG Ying-Qun

Abstract

A series of 4-arylmethylidene-3-methyl-4,5-dihydroisoxazol-5-one derivatives were synthesized by the condensation reactions of aromatic aldehydes with 3-methyl-4,5-dihydroisoxazol-5-one via room temperature grinding or heating under solvent-free conditions without any catalyst. The products were identified by ¹H NMR, IR, MS spectra and elemental analysis.

Key words: 4-arylmethylidene-3-methyl-4,5-dihydroisoxazol-5-one, condensation, ethyl acetoacetate, hydroxylamine hydrochloride, solvent-free, aromatic aldehyde, 3-methyl-4,5-dihydroisoxazol-5-one

Cite this article

ZHANG Ying-Qun*,WANG Chun,ZHANG Mei-Yue,CUI Peng-Lei
LI Yue-Min,ZHOU Xin,LI Jing-Ci. Condensation Reactions of Aromatic Aldehydes with 3-Methyl-4,5- dihydroisoxazol-5-one without Solvent and Catalyst[J]. Chin. J. Org. Chem., 2008, 28(05): 914-917.

Export EndNote|Reference Manager|ProCite|BibTeX|RefWorks

[1]	Yiwen Quan, Xinhui Jiang, Wenjun Li, Jian Wang. Access to α-Vinyl β-Alkynyl Enals via an Organocatalytic Deconjugation-Aldol Condensation Sequence [J]. Chinese Journal of Organic Chemistry, 2023, 43(6): 2120-2125.
[2]	Xinyu Zhang, Huihui Geng, Shilei Zhang, Wei Wang, Xiaobei Chen. A Method for the Synthesis of Deuterated Benzoins Catalyzed by N-Heterocyclic Carbene [J]. Chinese Journal of Organic Chemistry, 2023, 43(4): 1510-1516.
[3]	Xueli Zhu, Shaoli Yang, Caixia Jia, Jing Li, Zheng Duan. Synthesis of Dihydrobenzooxaphospholes via Cyclocondensation of 2-Phosphinylphenol and Aldehydes [J]. Chinese Journal of Organic Chemistry, 2022, 42(7): 2201-2213.
[4]	JIan Xiao, Zhiying Wu, Ziyi Chen, Pengfei Zhao. Tetraethylenepentamine Functionalized Phenolic Resin as Highly Active Acid-Base Bifunctional Catalyst for Knoevenagel Condensation Reaction [J]. Chinese Journal of Organic Chemistry, 2022, 42(4): 1179-1187.
[5]	Jing Shi, Pengfei Guo, Wei Li, Haijing Sun, Lingwu Meng, Xinli Tong. Copper(I)-Catalyzed Aerobic Oxidative Condensation of Biomass-Based Platform Compound Furfurals with Straight-Chain Alcohols [J]. Chinese Journal of Organic Chemistry, 2022, 42(3): 905-909.
[6]	Shuowen Wang, Pingyu Jiang, Rong Li, Muyang Yang, Guojun Deng. Progress in Selective Construction of Functional Aromatics with Cyclohexanone [J]. Chinese Journal of Organic Chemistry, 2022, 42(1): 129-146.
[7]	Wenxin Zhao, Mengjun Huang, Shengnan Li, Yujing Liu, Zhongqiu Liu, An'guo Ying. One-Pot Synthesis of 3,4-Dihydropyrimidine-2-one Derivatives via Biginelli Reactions Catalyzed by SnCl₂@MNPs [J]. Chinese Journal of Organic Chemistry, 2021, 41(7): 2743-2749.
[8]	Jun Zhang, Yafei Liu, Yurong Zhang, Liang Hu, Shiqing Han. Progress in Synthesis of 2-Substituted Benzothiazole Compounds [J]. Chinese Journal of Organic Chemistry, 2021, 41(3): 1053-1071.
[9]	Kun Zhou, Yangjie Mao, Fengwei Wu, Shaojie Lou, Danqian Xu. Recent Advances in C—H Bond Functionalization under Mechanochemical Conditions [J]. Chinese Journal of Organic Chemistry, 2021, 41(12): 4623-4638.
[10]	Zhanggao Le, Zhiyu Hu, Xuehua Chen, Liyuan Yan, Yishuai Liu, Zongbo Xie. Synthesis of Triarylmethane Derivatives by Baeyer Condensation in a Deep Eutectic Solvent [J]. Chinese Journal of Organic Chemistry, 2021, 41(11): 4415-4420.
[11]	Xueying Wang, Yee Lin Phang, Changwu Zheng, Hongxi Xu. Studies toward the Total Synthesis of Xanthochymol [J]. Chinese Journal of Organic Chemistry, 2021, 41(11): 4421-4427.
[12]	Yu Jieqiang, Jia Jun, Wang Xingwang. Synthesis of a Type of Linear β,γ-Unsaturated α-Keto Tryptophol Ester Compounds [J]. Chinese Journal of Organic Chemistry, 2020, 40(9): 2778-2787.
[13]	Shi Dapeng, Duan Zhongyu. Propargylamine Synthesis via Three-Component Coupling Reaction Catalyzed by Recyclable Cu Nanoparticles under Solvent-Free Conditions [J]. Chinese Journal of Organic Chemistry, 2020, 40(5): 1316-1322.
[14]	Ren Xinfeng, Song Xiaoping, Ma Yingchao, Li Ya. Method for the Synthesis of 1,1-Dichloroalkenes [J]. Chinese Journal of Organic Chemistry, 2020, 40(5): 1388-1393.
[15]	Wang Lingfeng, Qian Ying. Near-Infrared Quinoline-Fluoroborodipyrrole Dye: Synthesis and Lysosomal Fluorescence Imaging [J]. Chinese Journal of Organic Chemistry, 2020, 40(5): 1246-1250.

无溶剂无催化剂条件下芳香醛与3-甲基异噁唑-5-酮的缩合反应

Condensation Reactions of Aromatic Aldehydes with 3-Methyl-4,5- dihydroisoxazol-5-one without Solvent and Catalyst

PDF

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments