Interaction between Monosquaramide Macrocyclic Tetraamine Metal Complexes and DNA

Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (07): 1223-1226. Previous Articles Next Articles

Original Articles

单方酰化大环四胺金属配合物与DAN相互作用研究

向清祥; 陈稼轩 ; 杨孝容 ; 蔡显荣 ; 熊俊如

(乐山师范学院化学与生命科学系乐山 614004)

收稿日期:2007-01-22 修回日期:2008-02-08 发布日期:2008-07-28
通讯作者: 向清祥

Interaction between Monosquaramide Macrocyclic Tetraamine Metal Complexes and DNA

XIANG, Qing-Xiang* CHEN, Jia-Xuan; YANG, Xiao-Rong;
CAI, Xian-Rong ; XIONG, Jun-Ru

(Department of Chemistry and Life Science, Leshan Teachers College, Leshan 614004)

Received:2007-01-22 Revised:2008-02-08 Published:2008-07-28
Contact: XIANG, Qing-Xiang

Abstract

A monosquaramide macrocyclic tetraamine derived from 1,4,7,10-tetraazacyclododecane has been synthesized in this paper and its structure was characterized by 1H NMR, MS spectra and elemental analysis. Interactions of the target compound and its metal complexes of Cu(II), Ni(II) with CT (calf thymus) DNA have been investigated by the ultraviolet spectrophotometry. The results showed that the monosquaramide macrocyclic tetraamine and the base solvent have bathochromic effects on DNA, but its metal complexes have hypochromic effects on DNA.

Key words: macrocyclic polyamine, complex, CT DNA, monosquaramide

Cite this article

XIANG, Qing-Xiang* CHEN, Jia-Xuan; YANG, Xiao-Rong;
CAI, Xian-Rong ; XIONG, Jun-Ru
. Interaction between Monosquaramide Macrocyclic Tetraamine Metal Complexes and DNA[J]. Chin. J. Org. Chem., 2008, 28(07): 1223-1226.

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单方酰化大环四胺金属配合物与DAN相互作用研究

Interaction between Monosquaramide Macrocyclic Tetraamine Metal Complexes and DNA

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