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Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (03): 462-465. Previous Articles     Next Articles

Reports

ZnCl2温和有效地催化活泼亚甲基化合物与苄醇或烯丙醇的 直接烷基化反应

吴 俊a ; 叶家海*,b; 胡劲松a ; 王智勇b; 商永嘉*,a   

  1. (a安徽师范大学化学与材料科学学院 安徽省分子固体重点实验室 芜湖 241000)
    (b南京理工大学化工学院 南京 210094)
  • 收稿日期:2008-03-03 修回日期:2008-09-02 发布日期:2009-03-20
  • 通讯作者: 叶家海,商永嘉

A Mild and Highly Efficient ZnCl2-Catalyzed Direct Alkylation of Active Methylene Compounds with Benzylic and Allylic Alcohols

Wu, Juna ; Ye, Jiahai*,b; Hu, Jinsonga ; Wang, Zhiyongb; Shang, Yongjia*,a   

  1. (a Anhui Key Laboratory of Functional Molecular Solids, College of Science and Material Science,
    Anhui Normal University, Wuhu 241000)
    (b School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094)
  • Received:2008-03-03 Revised:2008-09-02 Published:2009-03-20
  • Contact: Ye, Jiahai; Shang, Yongjia

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A mild and highly efficient ZnCl2-catalyzed direct alkylation of active methylene compounds with benzylic and allylic alcohols has been reported. The alkylation was carried out in the presence of sub-stoichiometric amounts of anhydrous ZnCl2 (5～10 mol%) under reflux in dichloromethane with high yields. It is an easy handling and atomic-economic reaction and water is the only side product. The possible mechanism for this direct alkylation has preliminary studied as well.

Key words: alkylation, active methylene compound, ZnCl2-catalyzed