A series of ketone oxime ethers were synthesized by O-alkylation of ketone oxime with several alkylating agents such as alkyl halides and alkyl sulfates in ionic liquids. The O-alkylation reactions were conducted in 20～40 ℃ for 1～2 h, using ionic liquids [Bmim]PF₆, [Bmim]BF₄ and [Bmim]OH as medium and NaOH as acid binding agent. The yields of 52%～94% were obtained and the products were identified by ¹H NMR and GC-MS techniques. The study shows that the operation conditions are mild, the process is simple and green to environment, and the ionic liquids could be reused while maintaining good performance.

Key words: ionic liquid, ketone oxime, O-alkylation, O-alkyl ketone oxime ether