[Bmim]ZnBr3-Promoted Tandem Reaction of Enaminoester and Allenic Ketones for the Synthesis of Substituted Nicotinate Derivatives

doi:10.6023/cjoc201709019

Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (2): 498-503.DOI: 10.6023/cjoc201709019 Previous Articles Next Articles

Notes

[Bmim]ZnBr₃促进的烯胺酯和联烯酮的串联反应合成烟酸酯衍生物

张涛, 王强

河南理工大学化学化工学院焦作 45400

收稿日期:2017-09-13 修回日期:2017-10-17 发布日期:2017-10-31
通讯作者: 王强 E-mail:wangqiang@hpu.edu.cn
基金资助:
河南省教育厅自然科学技术研究重点（No.14A150048）资助项目.

[Bmim]ZnBr₃-Promoted Tandem Reaction of Enaminoester and Allenic Ketones for the Synthesis of Substituted Nicotinate Derivatives

Zhang Tao, Wang Qiang

College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo 454000

Received:2017-09-13 Revised:2017-10-17 Published:2017-10-31
Contact: 10.6023/cjoc201709019 E-mail:wangqiang@hpu.edu.cn
Supported by:
Project supported by the Natural Science Research Program from Education Department of Henan Province (No. 14A150048).

1. [Bmim]ZnBr₃-Promoted Tandem Reaction of Enaminoester and Allenic Ketones for the Synthesis of Substituted Nicotinate Derivatives.PDF(820KB)

Abstract

A novel approach for the synthesis of nicotinate derivatives has been developed by using Lewis acidic ionic liquid[Bmim]ZnBr₃, which acts as dual solvent-catalyst in promoting the tandem reaction of enaminoester and allenic ketones. In the reaction process, no catalysts or other organic solvents are used, and[Bmim]ZnBr₃ can be readily reused for three times without noticeable decrease in the catalytic activity after simple treatment. Furthermore, our method offers several advantages such as short reaction times, simple work-up procedure, environment-friendly solvent and good yields. The current methodology could also be conveniently applied to the synthesis of natural products and complex therapeutic agents occurring niacin frameworks.

Key words: ionic liquid, enaminoester, allenic ketone, nicotinate

Cite this article

Zhang Tao, Wang Qiang. [Bmim]ZnBr₃-Promoted Tandem Reaction of Enaminoester and Allenic Ketones for the Synthesis of Substituted Nicotinate Derivatives[J]. Chin. J. Org. Chem., 2018, 38(2): 498-503.

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[Bmim]ZnBr₃促进的烯胺酯和联烯酮的串联反应合成烟酸酯衍生物

[Bmim]ZnBr₃-Promoted Tandem Reaction of Enaminoester and Allenic Ketones for the Synthesis of Substituted Nicotinate Derivatives

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[Bmim]ZnBr3促进的烯胺酯和联烯酮的串联反应合成烟酸酯衍生物