Synthesis and Configuration of Novel Isoxazole Derivatives Contain-ing Pyrazole Moiety

Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (9): 1342-1346. Previous Articles Next Articles

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新型含吡唑基异噁唑衍生物的合成与表征

周英雷，沈松伟，刘方明

(杭州师范大学材料与化学化工学院杭州 310036)

收稿日期:2009-12-11 修回日期:2010-01-22 发布日期:2010-04-22
通讯作者: 周英雷 E-mail:zhouyl993@163.com
基金资助:
新型含多氮杂环嘧啶-2-（硫）酮及其稠杂环衍生物的绿色合成，活性测试和构效关系研究

Synthesis and Configuration of Novel Isoxazole Derivatives Contain-ing Pyrazole Moiety

ZHOU Ying-Lei, SHEN Song-Wei, LIU Fang-Ming

(College of Materials and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036)

Received:2009-12-11 Revised:2010-01-22 Published:2010-04-22
Contact: ZHOU Ying-Lei E-mail:zhouyl993@163.com

Abstract

Sixteen new isoxazole derivatives containing pyrazole moiety were synthesized simply and feasibly by chalcone 4 and substituted pyrazolohydroximinoyl chlorides 3 as stating materials through 1,3-dipolar cycloaddition reaction. The structures of 4,5-dihydro-3-(1-pnenyl-3-methyl-5-substituted-4-yl)- 5-aryl-4-aroylisoxazolines (5) were confirmed by IR, ¹H NMR, MS techniques and elemental analysis. Compound 5g was subjected to X-ray single crystal diffraction analysis to determine crystallographic structure.

Key words: pyrazole, 1,3-dipolar cycloaddition, isoxazole, crystallographic structure

Cite this article

ZHOU Ying-Lei, SHEN Song-Wei, LIU Fang-Ming. Synthesis and Configuration of Novel Isoxazole Derivatives Contain-ing Pyrazole Moiety[J]. Chin. J. Org. Chem., 2010, 30(9): 1342-1346.

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新型含吡唑基异噁唑衍生物的合成与表征

Synthesis and Configuration of Novel Isoxazole Derivatives Contain-ing Pyrazole Moiety

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