Microwave-Assisted Synthesis and Antibacterial Activity of 6-Alkoxy Rheins

Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (9): 1335-1341. Previous Articles Next Articles

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微波辐射下6-烷氧基大黄酸的合成及抑菌活性研究

朱小康¹，叶小利²，袁吕江¹，朱家颖¹，丁阳平¹，李学刚*^,1

(¹西南大学药学院重庆 400716)
(²西南大学生命科学院重庆 400716)

收稿日期:2009-10-23 修回日期:2010-02-02 发布日期:2010-04-21
通讯作者: 朱小康 E-mail:xiaokangzhu1982@yahoo.com.cn
基金资助:
国家级.国家自然科学基金

Microwave-Assisted Synthesis and Antibacterial Activity of 6-Alkoxy Rheins

Zhu Xiaokang¹ Ye Xiaoli² Yuan Luji-ang¹ Zhu Jiaying¹ Ding Yangping¹ Li Xuegang*^,1

(¹School of Pharmaceutical Science, Southwest University, Chongqing 400716)
(²School of Life Science, Southwest University, Chongqing 400716)

Received:2009-10-23 Revised:2010-02-02 Published:2010-04-21
Contact: ZHU Xiao-Ming E-mail:xiaokangzhu1982@yahoo.com.cn

Abstract

Five new 6-alkoxy rheins have been designed and synthesized through Williamson reaction, acetyl protection, oxidation reaction and deprotection. The effects of microwave and conventional method on the yield of 3-alkyl emodin derivatives were compared. The effects of different oxidants in the synthesis of 3a～3e were studied and the best oxidation conditions were found. All the structures have been confirmed by IR, ¹H NMR, MS and HRMS techniques. The minimal inhibitory concentration (MIC) assay indicated that antibacterial activity changes regularly, as the alkyl chain growth.

Key words: emodin, 6-alkoxy rhein, microwave, oxidation, antibacterial activity

Cite this article

ZHU Xiao-Kang, YE Xiao-Li, YUAN Lv-Jiang, ZHU Jia-Ying, DING Yang-Ping, LI Xue-Gang. Microwave-Assisted Synthesis and Antibacterial Activity of 6-Alkoxy Rheins[J]. Chin. J. Org. Chem., 2010, 30(9): 1335-1341.

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微波辐射下6-烷氧基大黄酸的合成及抑菌活性研究

Microwave-Assisted Synthesis and Antibacterial Activity of 6-Alkoxy Rheins

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