Synthesis and Biological Evaluation of Coumarin Schiff Base Deriva-tives as Novel Antitumor Inhibitors

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (05): 708-714. Previous Articles Next Articles

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香豆素西佛碱衍生物的合成及抗肿瘤活性研究

王辉¹，郑伟华¹，谢凤妮¹，宋化灿*^,2

(¹华南师范大学化学与环境学院广州 510006)
(²中山大学化学与化学工程学院广州 510275)

收稿日期:2010-09-02 修回日期:2010-11-08 发布日期:2010-12-30
通讯作者: 宋化灿 E-mail:yjhxhc@mail.sysu.edu.cn, cedc19@zsu.edu.cn, cesshc@mail.sysu.edu.cn

Synthesis and Biological Evaluation of Coumarin Schiff Base Deriva-tives as Novel Antitumor Inhibitors

Wang Hui¹ Zheng Weihua¹ Xie Fengni¹ Song Huacan*^,2

(¹School of Chemistry and Environment, South China Normal University, Guangzhou 510006)
(² School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275)

Received:2010-09-02 Revised:2010-11-08 Published:2010-12-30

A series of coumarin Schiff base analogues were synthesized. Their structures were characterized by ¹H NMR, ¹³C NMR, ESI-MS techniques and elemental analysis. Preliminary bioassays for in vitro antitumour activities against KB and KBv200 cells indicated that compounds 4a, 4b, 5b, 3d and 4d exhibited middle potent antitumour activities. The relatives of structure and activity were discussed.

Key words: coumarin derivative, Schiff base, antitumor activity, KB and KBv200

Cite this article

WANG Hui, ZHENG Wei-Hua, XIE Feng-Ni, SONG Hua-Can. Synthesis and Biological Evaluation of Coumarin Schiff Base Deriva-tives as Novel Antitumor Inhibitors[J]. Chin. J. Org. Chem., 2011, 31(05): 708-714.

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香豆素西佛碱衍生物的合成及抗肿瘤活性研究

Synthesis and Biological Evaluation of Coumarin Schiff Base Deriva-tives as Novel Antitumor Inhibitors

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