Mechanochemical Synthesis of 5-(2-Nitroalkyl) Meldrum Acids

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (08): 1258-1261. Previous Articles Next Articles

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机械研磨法合成5-(2-硝基烷基)米氏酸衍生物

楼海文，张婷，李凯，张蔓，李景华*

(浙江工业大学药学院杭州 310014)

收稿日期:2010-11-03 修回日期:2011-01-10 发布日期:2011-03-02
通讯作者: 李景华 E-mail:lijh@zjut.edu.cn

Mechanochemical Synthesis of 5-(2-Nitroalkyl) Meldrum Acids

LOU Hai-Wen, ZHANG Ting, LI Kai, ZHANG Man, LI Jing-Hua

(College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014)

Received:2010-11-03 Revised:2011-01-10 Published:2011-03-02
Contact: Jing-Hua Li E-mail:lijh@zjut.edu.cn

Mechanochemical synthesis of 5-(2-nitroalkyl) Meldrum acids from 5-alkylidene Meldrums acids and nitroalkanes in the presence of bases was achieved and the effect of bases and the ratio of reagents was discussed. This method is suitable for synthesis of various 5-(2-nitroalkyl) Meldrum acids which provides a green and efficient way for the synthesis of γ-aminobutyric acids.

Key words: mechanochemistry, 5-(2-nitroalkyl) Meldrum acid, γ-aminobutyric acid, precursor

Cite this article

LOU Hai-Wen, ZHANG Ting, LI Kai, ZHANG Man, LI Jing-Hua. Mechanochemical Synthesis of 5-(2-Nitroalkyl) Meldrum Acids[J]. Chin. J. Org. Chem., 2011, 31(08): 1258-1261.

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机械研磨法合成5-(2-硝基烷基)米氏酸衍生物

Mechanochemical Synthesis of 5-(2-Nitroalkyl) Meldrum Acids

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