Progress in the Synthesis of One Kind of α-Heterocycle Five-Membered Amino Acids

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (10): 1563-1572. Previous Articles Next Articles

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一类α-五元杂环氨基酸的合成研究进展

孙晓敏¹，张伟²，丁宁²，王鹏¹，李英霞*^,2

(¹中国海洋大学医药学院教育部海洋药物重点实验室青岛 266003)
(²复旦大学药学院上海 201203)

收稿日期:2011-01-05 修回日期:2011-03-13 发布日期:2011-03-21
通讯作者: 李英霞 E-mail:liyx417@fudan.edu.cn

Progress in the Synthesis of One Kind of α-Heterocycle Five-Membered Amino Acids

Sun Xiaomin¹ Zhang Wei² Ding Ning² Wang Peng¹ Li Yingxia*^,2

(¹School of Pharmacy, Ocean University of China, Qingdao 266003)
(²School of Pharmacy, Fudan University, Shanghai 201203)

Received:2011-01-05 Revised:2011-03-13 Published:2011-03-21

Amino acids containing five-membered heterocycles coming between the terminal carbonyl of the acid function and the α-carbon are a class of highly modified amino acids mainly from marine peptides. The five-membered heterocycles are pharmacophores of many natural and synthetic bioactive compounds. This review focuses on the progress of the synthetic methods of these amino acids (including the limitation, simplicity, yield and optical purity) in recent years.

Key words: α-heterocycle five-membered amino acids, cyclodehydration, biosynthesis, biomimetic synthesis

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SUN Xiao-Min, ZHANG Wei, DING Ning, WANG Peng, LI Ying-Xia. Progress in the Synthesis of One Kind of α-Heterocycle Five-Membered Amino Acids[J]. Chin. J. Org. Chem., 2011, 31(10): 1563-1572.

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一类α-五元杂环氨基酸的合成研究进展

Progress in the Synthesis of One Kind of α-Heterocycle Five-Membered Amino Acids

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