Pd/C-Catalyzed Reductive Coupling of Aryl Halides Using Formic Hydrazide as Reducing Agent

Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (07): 1259-1263. Previous Articles Next Articles

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钯碳催化下以甲酰肼为还原剂的卤代芳烃还原偶联反应研究

朱雯芳; 乔江彬 ; 卓广澜*

(浙江理工大学应用化学系杭州 310018)

收稿日期:2007-10-20 修回日期:2007-12-18 发布日期:2008-07-28
通讯作者: 卓广澜

Pd/C-Catalyzed Reductive Coupling of Aryl Halides Using Formic Hydrazide as Reducing Agent

ZHU, Wen-; QIAO, Jiang-Bin ; ZHUO, Guang-Lan*

(Department of Applied Chemistry, Zhejiang Sci-Tech University, Hangzhou 310018)

Received:2007-10-20 Revised:2007-12-18 Published:2008-07-28
Contact: ZHUO, Guang-Lan

Abstract

The reductive coupling of aryl halides to form the corresponding biaryls was effected with high selectivity in water, using formic hydrazide as a reducing agent in the presence of a catalytic amount of Pd/C. Various substituted aryl halides proceed smoothly to afford the corresponding biaryls with good yields in the range of 52%～94%.

Key words: aryl halide, reductive coupling reaction, formic hydrazide, Pd/C, biaryl

Cite this article

ZHU, Wen-; QIAO, Jiang-Bin ; ZHUO, Guang-Lan*. Pd/C-Catalyzed Reductive Coupling of Aryl Halides Using Formic Hydrazide as Reducing Agent[J]. Chin. J. Org. Chem., 2008, 28(07): 1259-1263.

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钯碳催化下以甲酰肼为还原剂的卤代芳烃还原偶联反应研究

Pd/C-Catalyzed Reductive Coupling of Aryl Halides Using Formic Hydrazide as Reducing Agent

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