Chin. J. Org. Chem. ›› 2001, Vol. 21 ›› Issue (3): 235-237. Previous Articles     Next Articles

N-取代环十二酮缩氨基硫脲的氧化环合反应

张振业;金淑惠;梁晓梅;王志强;王道全   

  1. 中国农业大学应用化学系;农药化学及农药使用技术农业部重点开放实验室
  • 发布日期:2001-03-25

Oxidative cyclisation of N-substituted cyclododecanone thiosemicarbazones

Zhang Zhenye;Jin Shuhui;Liang Xiaomei;Wang Zhiqiang;Wang Daoquan   

  • Published:2001-03-25

N-Substituted cyclododecanone thiosemicarbazones Ⅰ, prepared from cyclododecanone, undergo oxidative cyclisation on treatment with manganese dioxide giving 2-(1,11-undecylidene) -5-substituted imino-△ ^3-1,3,4-thiadiazolines Ⅱ. The structures of Ⅱ were confirmed by IR, 13^C NMR and elemental analysis. A by-product was separated from the reaction mixture and its structure was assigned as 2-(1,11- undecylidene)-5-imino- △ ^3-1,3,4-thiadiazoline Ⅲ by IR, 13^C NMR, EIMS and elemental analysis. A two-step reaction mechanism for the oxidative cyclisation of Ⅰ on manganese dioxide was proposed to explain the formation of Ⅱ and Ⅲ.

Key words: THIOSEMICARBAZONE P, DODECAMEMBER RING COMPOUNDS, MANGANESE DIOXIDE, OXIDATION REACTION, SYNTHESIS METHODS, CYCLIZATION, REACTION MECHANISM, THIADIAZOLE P

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