Synthesis of 8,9-dihydro-2H-pyrano-[5,6-g] quinolin-2-  one derivatives

Chin. J. Org. Chem. ›› 2001, Vol. 21 ›› Issue (3): 231-234. Previous Articles Next Articles

8,9-二氢-2H-吡喃并[5,6-g]喹啉-2-酮衍生物的合成

郑云红;夏奕;杨征宇;张倩;陈瑛;夏鹏

复旦大学药学院有机化学教研室;原上海医科大学药学院;Natural Products Laboratory, School of Pharmacy, University;of North Carolina, Chapel Hill

发布日期:2001-03-25

Synthesis of 8,9-dihydro-2H-pyrano-[5,6-g] quinolin-2- one derivatives

Zheng Yunhong;Xia Yi;Yang Zhengyu;Zhang Qian;Chen Ying;Xia Peng

Published:2001-03-25

Abstract

A concise synthesis of 8,9-dihydro-2H-pyrano-[5,6-g]quinolin- 2-one derivatives was reported, using 3-amino-phenol as starting material. Treatment of 3-amino-phenol with ketones bearing αC-H at the presence of a catalyst PTS· H2O affords compound 2a～2d , followed by treatment with ethyl acetoacetate, gives target compound 3a～3d with regioselectivity.

Key words: QUINOLINE P, PYRANONE P, HETEROCYCLIC COMPOUNDS, TRICYCLIC HYDROCARBON P, BIOLOGICAL ACTIVITY, P- METHYLBENZENESULFONIC, AMINOPHENOL, REGION, SELECTIVITY, SYNTHESIS METHODS

CLC Number:

O629

Cite this article

Zheng Yunhong;Xia Yi;Yang Zhengyu;Zhang Qian;Chen Ying;Xia Peng. Synthesis of 8,9-dihydro-2H-pyrano-[5,6-g] quinolin-2- one derivatives[J]. Chin. J. Org. Chem., 2001, 21(3): 231-234.

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8,9-二氢-2H-吡喃并[5,6-g]喹啉-2-酮衍生物的合成

Synthesis of 8,9-dihydro-2H-pyrano-[5,6-g] quinolin-2- one derivatives

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