Chin. J. Org. Chem. ›› 1999, Vol. 19 ›› Issue (2): 157-161. Previous Articles     Next Articles

Original Articles

3-取代胺甲基-5-连三唑基-1, 3, 4-恶二唑-2-硫酮的合成

于建新;鲁文杰;刘罡;刘育亭;刘方明;陈耀祖   

  1. 新疆大学化学系.新疆(830046);五邑大学化学工程系;浙江大学化学系.杭州 (310027)
  • 发布日期:1999-04-25

Synthesis of 3-substituted aminomethyl-5-v-triazol-4-yl-1, 3, 4- oxadiazole-2-thione

Yu Jianxin;Lu Wenjie;Liu Gang;Liu Yuting;Liu Fangming;Chen Yaozu   

  1. Xinjiang Univ, Dept Chem.Xinjiang(830046);Zhejiang Univ, Dept Chem. Hangzhou(310027)
  • Published:1999-04-25

In the presence of CS~2/KOH, 2-phenyl-1, 2, 3-triazole-4-formyl hydrazine(1) cyclizes to give 5-(2-phenyl-1, 2, 3-triazol-4-yl)-1, 3, 4-oxadiazole-2-thione(2) which in turn is converted to 3-substituted aminomethyl-5-(2-phenyl-1, 2, 3-triazol-4-yl)-1, 3, 4-oxadiazole-2- thiones(3) under Mannich conditions.

Key words: THIOKETONE, BIOLOGICAL ACTIVITY, CARBON DISULFIDE, POTASSIUM HYDROXIDE, PYRRODIAZOLE P

CLC Number: