The synthesis of indozoles from substituted hydranones  of 2, 6- dialkoxyl(hydroxyl) acetophenones

Chin. J. Org. Chem. ›› 1999, Vol. 19 ›› Issue (2): 162-165. Previous Articles Next Articles

Original Articles

2, 6-二烷氧基(羟基)苯乙酮的苄腙和甲腙合成吲唑类化合物

邱国福;邱玉珠;张正;胡宏纹

南京大学化学化工学院化学系

发布日期:1999-04-25

The synthesis of indozoles from substituted hydranones of 2, 6- dialkoxyl(hydroxyl) acetophenones

Qiu Guofu;Qiu Yuzhu;Zhang Zheng;Hu Hongwen

Published:1999-04-25

Abstract

In the presence of PPA, 2, 6-dialkoxyl (hydroxyl) acetophenone hydrazones were cyclized to give indazoles. According to the experimental resutls, it was assumed that the cyclization was taken by nucleophilic attack. All the new compound were identified by elemental and spectral analyses.

Key words: MASS SPECTROGRAPHY, INDAZOLE P, INFRARED SPECTROPHOTOMETRY, ELEMENTAL ANALYSIS, PROTON MAGNETIC RESONANCE SPECTROMETRY, ACETOPHENONE P, CYCLIZATION, HYDRAZONE P

CLC Number:

O621

Cite this article

Qiu Guofu;Qiu Yuzhu;Zhang Zheng;Hu Hongwen. The synthesis of indozoles from substituted hydranones of 2, 6- dialkoxyl(hydroxyl) acetophenones[J]. Chin. J. Org. Chem., 1999, 19(2): 162-165.

[1]	Baochang Gao, Yu Shi, Yuan Tian, Zhiguo Zhang, Jingru Zhang, Yufeng Sun, Guoliang Mao, Lingyan Dai. Synthesis of 4-Methyl-2-oxo-6-arylamino-2H-pyran-3-carbonitrile Derivatives [J]. Chinese Journal of Organic Chemistry, 2024, 44(2): 644-649.
[2]	Jing Tang, Wenkun Luo, Jun Zhou. Advances in the Synthesis of Azaspiro[4.5]trienones [J]. Chinese Journal of Organic Chemistry, 2023, 43(9): 3006-3034.
[3]	Yingke Feng, He Wang, Mengxing Cui, Ran Sun, Xin Wang, Yang Chen, Lei Li. Visible-Light-Induced Difluoroalkylated Cyclization of Novel Functionalized Aromatic Isocyanides [J]. Chinese Journal of Organic Chemistry, 2023, 43(8): 2913-2925.
[4]	Yuzhuo Chen, Hongmei Sun, Liang Wang, Fangzhi Hu, Shuaishuai Li. Research Progress on Construction of Heterocyclic Skeletons Based on α-Hydride Transfer Strategy [J]. Chinese Journal of Organic Chemistry, 2023, 43(7): 2323-2337.
[5]	Lixing Sun, Tingting Sun, Haiqing Wang, Shufang Wu, Xiaoye Wang, Tianya Liu, Yuchen Zhang. Lewis Acid-Catalyzed [2+4] Cyclization of 3-Alkyl-2-vinylindoles with α,β-Unsaturated N-Sulfonyl Ketimines [J]. Chinese Journal of Organic Chemistry, 2023, 43(6): 2178-2188.
[6]	Zhijun Ren, Weiwei Luo, Jun Zhou. Recent Progress in Silver-Mediated Tandem Cyclization of N-Arylacrylamides [J]. Chinese Journal of Organic Chemistry, 2023, 43(6): 2026-2039.
[7]	Rongbin Cai, Bing Li, Qi Zhou, Longyi Zhu, Jun Luo. Synthesis of 4,8,9,10-Tetrafunctionalized 2-Azaadamantanes and Their 2-Azaprotoadamantane Skeleton Isomers [J]. Chinese Journal of Organic Chemistry, 2023, 43(6): 2217-2225.
[8]	Jingpeng Li, Shuntao Huang, Qi Yang, Weiqiang Li, Teng Liu, Chao Huang. A Practical Synthesis of (Z)-N-Vinyl Substituted N,O-Acetals under Continuous Flow Technology [J]. Chinese Journal of Organic Chemistry, 2023, 43(4): 1550-1558.
[9]	Nan Jiang, Guanjie Huang, Yan Hu, Bo Wang. Ruthenium-Catalyzed C—H [4＋2] Annulation of Quinazolinones with Vinylene Carbonate [J]. Chinese Journal of Organic Chemistry, 2023, 43(4): 1537-1549.
[10]	Zhen Tang, Chao Pi, Yangjie Wu, Xiuling Cui. Rhodium-Catalyzed Tandem Acylmethylation/Annulation Reactions of 2-Aryl-2H-indazoles with Sulfoxonium Ylides: Easy Access to 6-Arylindazolo[2,3-a]quinolines [J]. Chinese Journal of Organic Chemistry, 2023, 43(3): 1187-1196.
[11]	Chengfu Zeng, Yuan He, Qing Li, Lin Dong. Ir(III)-Catalyzed Novel Three-Component Cascade Trifluoroethoxylation and One-Pot Method to Construct Complex Amide Compounds [J]. Chinese Journal of Organic Chemistry, 2023, 43(3): 1115-1123.
[12]	Haiqing Wang, Shuang Yang, Yuchen Zhang, Feng Shi. Advances in Catalytic Asymmetric Reactions Involving o-Hydroxybenzyl Alcohols [J]. Chinese Journal of Organic Chemistry, 2023, 43(3): 974-999.
[13]	Jinxiao Zhao, Tonghui Wei, Sen Ke, Yi Li. Visible Light-Catalyzed Synthesis of Difluoroalkylated Polycyclic Indoles [J]. Chinese Journal of Organic Chemistry, 2023, 43(3): 1102-1114.
[14]	Wenting Wei, Zhuangzhuang Li, Wandi Li, Jiaqi Li, Xianying Shi. Green Method for Constructing Phthalides via Oxidative Coupling of Aromatic Acids and Acrylates in Neat Water and Air [J]. Chinese Journal of Organic Chemistry, 2023, 43(3): 1177-1186.
[15]	Tian Sang, Fan Jia, Jing He, Chuntian Li, Yan Liu, Ping Liu. I₂-Catalyzed Cyclization of β-Ketonitrile with 1H-Pyrazol-5-amine [J]. Chinese Journal of Organic Chemistry, 2023, 43(1): 195-201.

2, 6-二烷氧基(羟基)苯乙酮的苄腙和甲腙合成吲唑类化合物

The synthesis of indozoles from substituted hydranones of 2, 6- dialkoxyl(hydroxyl) acetophenones

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments