Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (01): 55-60. Previous Articles     Next Articles

Original Articles

聚乙二醇支持的2,5-二取代异噁唑啉衍生物的液相合成

何心伟; 金 杰; 王翠娥 ; 商永嘉*   

  1. (安徽师范大学化学与材料科学学院 安徽省分子固体重点实验室 芜湖 241000)
  • 收稿日期:2008-04-11 修回日期:2008-06-11 发布日期:2009-01-20
  • 通讯作者: 商永嘉*

Synthesis of 2,5-Disubstituted Isoxazolines Using Poly(ethylene glycol) as Soluble Polymer Support

He, Xinwei ; Jin, Jie ; Wang, Cuie; Shang, Yongjia*   

  1. (Anhui Key Laboratory of Functional Molecular Solids, College of Chemistry and Materials Science,
    Anhui Normal University, Wuhu 241000)
  • Received:2008-04-11 Revised:2008-06-11 Published:2009-01-20
  • Contact: Shang, Yongjia*

An efficient liquid-phase synthesis of 2,5-disubstituted isoxazolines through a 1,3-dipolar cycloaddition is described. The poly(ethylene glycol) (PEG)-supported alkene reacted with nitrile oxides generated in situ from aldoximes, followed by cleavage from the PEG, to give isoxazolines in good yields and purities.

Key words: isoxazoline, liquid-phase organic synthesis, 1,3-dipolar cycloaddition., poly(ethylene glycol)