Progress in Palladium-Catalyzed Synthesis of Pyrimidine  Nucleoside Derivatives

Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (01): 44-54. Previous Articles Next Articles

Review

钯催化合成嘧啶核苷衍生物的研究进展

靳玄烨^a ; 肖强^*,b; 巨勇*,a

(a清华大学化学系生命有机磷与化学生物学教育部重点实验室北京 100084)
(b 江西科技师范学院有机功能分子重点实验室南昌330013)

收稿日期:2007-11-08 修回日期:2008-06-03 发布日期:2009-01-20
通讯作者: 肖强*,b; 巨勇*,a

Progress in Palladium-Catalyzed Synthesis of Pyrimidine Nucleoside Derivatives

Jin, Xuanye^a ; Xiao, Qiang^*,b ; Ju, Yong^*,a

(a Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education,
Department of Chemistry, Tsinghua University, Beijing 100084)
(bJiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013)

Received:2007-11-08 Revised:2008-06-03 Published:2009-01-20
Contact: Xiao, Qiang*,b ; Ju, Yong*,a

Abstract

Pyrimidine nucleosides are of great importance for medicinal chemistry, biological probe and nucleic acid. Palladium-catalyzed formation of carbon-carbon bond has found broad application to the synthesis of pyrimidine nucleoside derivatives. In this paper, the application and mechanism of some important palladium-catalyzed reactions used for the synthesis of pyrimidine nucleoside derivatives are summarized, which include Sonogashira reaction, Stille reaction, Heck reaction and Hiyama reaction.

Key words: Sonogashira reaction, Hiyama reactio, Stille reaction, Heck reaction, pyrimidine nucleoside

Cite this article

Jin, Xuanye^a ; Xiao, Qiang^*,b ; Ju, Yong^*,a. Progress in Palladium-Catalyzed Synthesis of Pyrimidine Nucleoside Derivatives[J]. Chin. J. Org. Chem., 2009, 29(01): 44-54.

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钯催化合成嘧啶核苷衍生物的研究进展

Progress in Palladium-Catalyzed Synthesis of Pyrimidine Nucleoside Derivatives

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