The carbon-carbon double bond is one of the most fundamental functional groups in organic chemistry. In the ever-expanding modern organic synthesis methods, the Ramberg-Backlund reaction continues to occupy a prominent position among various methods for the construction of carbon-carbon double bond. On treament with base, a-halo sulfones were converted into alkenes via Ramberg-Backlund reaction. It is now understood that the reaction takes place via 1, 3-elimination of HX from the a-halo sulfones, and loss of SO-2 from the resulting thiirane 1,1-dioxide. Because Ramberg-Backlund reaction has good stereoselective, it provides convenient and versatile route to polysubstituted alkenes. In this review, we focus on the modification and application of Ramberg-Backlund reaction. The research works in our laboratory are also discussed.

Key words: CONJUGATED DOUBLE BOND COMPOUNDS, SELECTIVITY, CARBON-CARBON BOND