Chin. J. Org. Chem. ›› 2003, Vol. 23 ›› Issue (11): 1198-1204. Previous Articles     Next Articles

布洛芬合成绿色化进展

于凤丽;赵玉亮;金子林   

  1. 大连理工大学
  • 发布日期:2003-11-25

Progress on Synthesis of Ibuprofen with Green Methodology

Yu Fengli;Zhao Yuliang;Jin Zilin   

  1. State Key Laboratory of Fine Chemicals, Dalian University of Technology
  • Published:2003-11-25

The synthetic methods for ibuprofen, an anti-inflammatory drug, are introduced. Emphases are Boots/ Hoechst-Celanese (BHC) process with the fame of cleaner prodution and the recent progress on synthesis of ibuprofen with green methodology. Especially the environmentally friendly recovery of catalyst and the asymmetric carbonylation of p- isobutylstyrene for preparing ibuprofen are reviewed.

Key words: ANALGESICS ANTI-INFLAMMATORY, STYRENE P, ISOBUTYL GROUP, CARBONYLATION

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