Studies on the acylthiosemicarbazides and their related heterocyclic derivatives V: Synthesis of 1-β -morpholinopropionyl)-4-arylthiosemicarbazides and related heterocyclic derivatives

Abstract

Title compounds I (R = H, 4-Me, 4-Cl, 2,4-Me2, 2-Me, 4-MeO) were prepared by refluxing b-morpholinopropionyl hydrazide with aryl isothiocyanates. Acid or base treatment of I gave thiadiazoles II (R = H, 4-Me, 4-Cl, 2,4-Me2, 2-Me) or triazolinethiones III (R = 4-Me, 4-MeO) resp. II (R = 4-Cl) showed tuberculostatic and plant growth regulator activity.

Key words: THIOKETONE, METHYLACETIC ACID P, BIOLOGICAL ACTIVITY, NITROGEN HETEROCYCLICS, MORPHOLINE P, HYDRAZIDE, ISOTHIOCYANATE, ANTITUBERCULAR AGENTS, THIADIAZOLE P, PYRRODIAZOLE P, THIOSEMICARBAZIDE P

CLC Number:

O621

Cite this article

ZHANG ZIYI;YANG HU. Studies on the acylthiosemicarbazides and their related heterocyclic derivatives V: Synthesis of 1-β -morpholinopropionyl)-4-arylthiosemicarbazides and related heterocyclic derivatives[J]. Chin. J. Org. Chem., 1988, 8(2): 153-152.

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