Ten 3-aryl-1,2,4-triazol-5-alkylsulfides were prepared by the reaction of 3-aryl-5-mercapto-1,2,4-triazoles with chloroacetic acid and ethyl bromoacetate in the presence of a base. Five 3-arylthiazolo[2,3-c]- s-triazol-5(6H)-ones were synthesized by cyclization under the condition of microwave irradiation. Ten 3-aryl-6,7-dihydro-s-triazolo[3,4-b] [1,3]thiazine and 3-aryl-5,6-dihydrothiazolo[2,3-c]-s-riazoles were synthesized by nucleophilicsubstitution of 3-aryl-5-mercapto-1,2,4- triazoles with dihalohydrocarbon 1,2-dichloroethane and 1,3- dibromopropane in isopropanol and alkaline media. The structure of all compounds were characterized by elemental analysis, IR, ^1H NMR and MS. The compounds have been evaluated for their antibacterial activity against E.Coli, B.Sub, S.Aur. Compound 3a showed anticancer activity.

Key words: NUCLEOPHILIC REACTION, ACETIC ACID P, THIAZINE P, BIOLOGICAL ACTIVITY, PYRRODIAZOLE P, CYCLIZATION, ORGANIC SYNTHESIS, MERCAPTO COMPOUNDS, SUBSTITUTION REACTION, THIAZOLE P