Phosphatidylcholines and their analogs, the functional building block of the membrane, are recently found to mediate multiple physiological and pathological processes. Besides acting as the phopholipase inhibitor and platelet activating factor, phospholipids exhibit the membrane-directing biological activities, e.g. antineoplastic cytotoxicity, potential anti-AIDS agent and antifungal activity. So the phospholipid analogs represent a new class of potent biologically active compounds with a wide range of desirable pharmacological effects.

Key words: PHOSPHOLIPASE, PHOSPHATIDYL CHOLINE, PLATELET, PHYSICOCHEMICAL CHARACTERISTICS, ANTITUMOR DRUGS, ACTIVATION, ENZYME INHIBITOR, FACTOR, ANTIFUNGAL AGENTS, BIOLOGICAL ACTIVITY