1,3-Dipolar Cycloaddition of Pyridinium Ylides to Chalcone for Preparation of 3-Acetyl-2-phenyl-indolizine

Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (11): 1587-1589. Previous Articles Next Articles

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吡啶叶立德与查尔酮1,3-偶极环加成反应制备2-苯基-3-乙酰基中氮茚

王炳祥*，徐助雄，吴婧

(南京师范大学化学与环境科学学院江苏省生物医药功能材料工程研究中心南京 210097)

收稿日期:2005-11-26 修回日期:1900-01-01 发布日期:2006-10-27
通讯作者: 王炳祥

1,3-Dipolar Cycloaddition of Pyridinium Ylides to Chalcone for Preparation of 3-Acetyl-2-phenyl-indolizine

WANG Bing-Xiang*,XU Zhu-Xiong,WU Jing

(Jiangsu Research Center of Biomedical Functional Materials Engineering, College of Chemistry and Environment Science, Nanjing Normal University, Nanjing 210097)

Received:2005-11-26 Revised:1900-01-01 Published:2006-10-27
Contact: WANG Bing-Xiang

Abstract

3-Acetyl-2-phenyl-indolizine was prepared in 37% yield by 1,3-dipolar cycloaddition of pyridinium N-ylides and chalcone promoted by oxidant such as CrO₃/Et₃N. Under the similar conditions, 1,3-dipolar cycloaddition of isoquinolinium N-ylides and chalcone induced by oxidant such as CrO₃/Et₃N promoted gave the corresponding (1-benzoyl-2-phenyl-pyrrolo[2,1-a]isoquinolin-3-yl)-ethanone in 58% yield.

Key words: 3-acetyl-2-phenyl-indolizine, pyridinium ylide, chalcone, 2-phenyl-pyrrolo[2,1-a]isoquinolin-3-yl)-ethanone

Cite this article

WANG Bing-Xiang*,XU Zhu-Xiong,WU Jing. 1,3-Dipolar Cycloaddition of Pyridinium Ylides to Chalcone for Preparation of 3-Acetyl-2-phenyl-indolizine[J]. Chin. J. Org. Chem., 2006, 26(11): 1587-1589.

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吡啶叶立德与查尔酮1,3-偶极环加成反应制备2-苯基-3-乙酰基中氮茚

1,3-Dipolar Cycloaddition of Pyridinium Ylides to Chalcone for Preparation of 3-Acetyl-2-phenyl-indolizine

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