Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (9): 1094-1099. Previous Articles     Next Articles

Original Articles

天然产物()-Patriscabrol和()-Isopatriscabrol的全合成研究

谢平*,焦晓臻,陈淑凤,梁晓天   

  1. (中国协和医科大学 中国医学科学院药物研究所 北京 100050)
  • 收稿日期:2004-11-09 修回日期:2005-04-30 发布日期:2005-08-24
  • 通讯作者: 谢平

Study of Synthesis of Natural Product ()-Patriscabrol and ()-Isopatriscabrol

XIE Ping*,JIAO Xiao-Zhen,CHEN Shu-Feng,LIANG Xiao-Tian   

  1. (Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050)
  • Received:2004-11-09 Revised:2005-04-30 Published:2005-08-24
  • Contact: XIE Ping

(-)-Patriscabrol and (+)-isopatriscabrol have been synthesized via fumaryl chloride and L-menthol as starting material in fourteen steps with the total yield about 4.6%. The structures of the products were confirmed by 1H NMR, MS, NOE, HMBC and HMQC spectra.

Key words: (+)-isopatriscabrol, total synthesis, (-)-patriscabrol, Patrinia Scabra