Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (03): 389-394. Previous Articles     Next Articles

Reviews

无溶剂条件下脯氨酸甲酯催化syn选择性羟醛缩合反应

彭以元*,a,b,崔明a,毛雪春a,叶伟c   

  1. (a江西师范大学化学化工学院 江西省绿色化学重点实验室 南昌 330022)
    (b江西师范大学生命科学学院 南昌 330022)
    (c防化指挥工程学院化学系 北京 102205)
  • 收稿日期:2009-08-30 修回日期:2009-10-15 发布日期:2010-03-28
  • 通讯作者: 彭以元 E-mail:yiyuanpeng@yahoo.com

syn-Selective Aldol Reactions Catalyzed by Proline Methyl
Ester under Solvent-Free Conditions

Peng Yiyuan*,a,b,Cui Minga,Mao Xuechuna,Ye Weic   

  1. (a Jiangxi' Key Laboratory of Green Chemistry, College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022)
    (b College of Life Science, Jiangxi Normal University, Nanchang 330022)
    (c Department of Chemistry, Institute of Chemical Defense, Beijing 102205)
  • Received:2009-08-30 Revised:2009-10-15 Published:2010-03-28

L-Proline ester catalyzed aldol reaction of cyclopentanone with a variety of aldehdes under solvent-free conditions was investigated. Good to excellent yields with syn diastereoselectivity (up to 100% de) were obtained via catalysis by L-proline methyl ester.

Key words: L-proline ester, organocatalysis, aldol reaction, solvent-free, syn-diastereoselectivity