Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (03): 395-400. Previous Articles     Next Articles

Reviews

取代苯甲醛的取代基在硝基苄基鏻参与的Wittig反应中对二苯乙烯分子构型的影响

曹晨忠*,刘立秋,陈冠凡,周再春,蒋荣清,卢冰涛   

  1. (湖南科技大学化学化工学院 湘潭 411201)
    (湖南科技大学理论化学与分子模拟省部共建教育部重点实验室 湘潭 411201)
    (湖南科技大学分子构效关系湖南省普通高等学校重点实验室 湘潭 411201)
  • 收稿日期:2009-05-30 修回日期:2009-07-16 发布日期:2010-03-28
  • 通讯作者: 曹晨忠 E-mail:czcao@hnust.edu.cn
  • 基金资助:

    国家级.国家自然科学基金

Effect of Substituents on the Configuration of Stilbene Derivatives in Wittig Reaction of Substituted Benzaldehyde with
Nitro-benzyltriphenylphosphonium Salt

Cao Chenzhong*,Liu Liqiu,Chen Guanfan,Zhou Zaichun
Jiang Rongqing,Lu Bingtao   

  1. (School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201)
    (Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education,
    Hunan University of Science and Technology, Xiangtan 411201)
    (Hunan Provincial University Key Laboratory of QSAR/QSPR, Hunan University of Science and
    Technology, Xiangtan 411201)
  • Received:2009-05-30 Revised:2009-07-16 Published:2010-03-28

A series of nitro-containing stilbene derivatives were synthesized by Wittig reaction of substituted benzaldehyde with nitro-benzyltriphenylphosphonium salt. It was observed that the configuration of the stilbene derivatives depended on the substituents of the substituted benzaldehyde, when the Wittig reactions were carried out in CH2Cl2. The main products are the E-stilbene for the substituents NMe2, OMe, Me, Cl and H, but the Z-stilbene for the substituents CN and NO2. Furthermore the comparison of the Z/E ratio in the reactions of three benzyltriphenylphosphonium salts with six substituted benzaldehydes was made. The results showed that the Z/E ratio of stilbene products diminished as the substituent electron withdrawing effect of group Y in the benzaldehyde decreased in the reaction of p-NO2C6H4CH2PPh3 with YC6H4CHO, while the above Z/E change trend was not observed in the reactions of PhCH2PPh3, p-MeC6H4CH2PPh3 with YC6H4CHO, respectively. The molecular configuration of the target compounds was identified through the determination of their crystal structures, and their structures were also deliberately characterized by 1H NMR, GC-MS, IR and UV-Vis techniques.

Key words: stilbene, nitro-benzyltriphenylphosphonium, substituted benzaldehyde, crystal structure, molecular configuration

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