Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (10): 1559-1562. Previous Articles     Next Articles

Notes

双螺环哌嗪季铵盐类化合物的合成及镇痛活性研究

王欣,刘文俊,李刚,叶加,程铁明,李润涛   

  1. (北京大学药学院天然药物及仿生药物国家重点实验室 北京 100191)
  • 收稿日期:2010-05-05 修回日期:2010-05-19 发布日期:2010-05-19
  • 通讯作者: 王欣 E-mail:xinwang@bjmu.edu.cn
  • 基金资助:

    国家自然科学基金

Synthesis and Analgesic Activity of Dispirocyclopiperazinium Ana-logues

WANG Xin, LIU Wen-Jun, LI Gang, YE Jia, CHENG Tie-Ming, LI Run-Tao   

  1. (State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191)
  • Received:2010-05-05 Revised:2010-05-19 Published:2010-05-19
  • Contact: vivian Wang E-mail:xinwang@bjmu.edu.cn

A series of dispirocyclopiperazinium analogues were synthesized by the reaction of hexanedioyl chloride, piperazine analogues and dibromides. The structures of target compounds were characterized by 1H NMR, 13C NMR spectra and elemental analysis. Preliminary bioassay test indicated that most of the compounds showed significant analgesic activity, and the structure-activity relationship was revealed.

Key words: piperazine, spirocyclopiperazinium, synthesize, analgesic activity, structure-activity relationship