Synthesis of 1,3,5-Triaryl-2-aroylcyclohexanol Derivatives and Crys-tal Structure under Solvent-Free Conditions

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (07): 1064-1068. Previous Articles Next Articles

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无溶剂合成1,3,5-三芳基-2-芳酰基环己醇衍生物和晶体结构

刁晓菊¹，季红楼²，殷姗²，荣良策*^,2，屠树江²

(¹徐州医学院徐州 221004)
(²徐州师范大学化学化工学院徐州 221116)

收稿日期:2010-10-27 修回日期:2011-02-04 发布日期:2011-03-04
通讯作者: 荣良策 E-mail:lcrong@xznu.edu.cn

Synthesis of 1,3,5-Triaryl-2-aroylcyclohexanol Derivatives and Crys-tal Structure under Solvent-Free Conditions

Diao Xiaoju¹ Ji Honglou² Yin Shan² Rong Liangce*^,2 Tu Shujiang²

(¹Xuzhou Medical College, Xuzhou 221004)
(² College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116)

Received:2010-10-27 Revised:2011-02-04 Published:2011-03-04
Contact: Rong LiangCe E-mail:lcrong@xznu.edu.cn

An efficient synthesis of 1,3,5-triaryl-2-aroylcyclohexanol derivatives from chalcone and malononitrile was reported in the presence of sodium hydroxide under solvent-free conditions at room temperature. The advantages of this procedure were simple protocol, high yields and environment friendliness. Their structures were determined by IR, ¹H NMR spectra, elemental analysis and HRMS spectra, and 3b was additionally confirmed by X-ray diffraction analysis.

Key words: chalcone, malononitrile, solvent-free, grinding, environment friendliness

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DIAO Xiao-Ju, JI Hong-Lou, YIN Shan, RONG Liang-Ce, TU Shu-Jiang. Synthesis of 1,3,5-Triaryl-2-aroylcyclohexanol Derivatives and Crys-tal Structure under Solvent-Free Conditions[J]. Chin. J. Org. Chem., 2011, 31(07): 1064-1068.

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无溶剂合成1,3,5-三芳基-2-芳酰基环己醇衍生物和晶体结构

Synthesis of 1,3,5-Triaryl-2-aroylcyclohexanol Derivatives and Crys-tal Structure under Solvent-Free Conditions

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