Synthesis and Photoactivated Activity of Thiophene Conjugated with N-Aryl Pyrazole Derivatives

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (9): 1452-1459. Previous Articles Next Articles

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噻吩N-芳基吡唑类化合物的合成及光活化活性研究

袁李青，徐汉虹*，杨文，李娜

(华南农业大学昆虫毒理研究室天然农药与化学生物学教育部重点实验室广州 510642)

收稿日期:2011-01-09 修回日期:2011-03-31 发布日期:2011-04-27
通讯作者: 徐汉虹 E-mail:hhxu@scau.edu.cn

Synthesis and Photoactivated Activity of Thiophene Conjugated with N-Aryl Pyrazole Derivatives

YUAN Li-Qing, XU Han-Hong, YANG Wen, LI Na

(Laboratory of Insect Toxicology & Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, South China Agricultural University, Guangzhou 510642)

Received:2011-01-09 Revised:2011-03-31 Published:2011-04-27

Twelve novel thiophene conjugated with N-aryl pyrazole derivatives 5a～5l were synthesized from 2,6-dichloro-4-trifluoromethylaniline with 2-bromothiophene, and characterized by ¹H NMR, ¹³C NMR, MS techniques and elemental analysis. Preliminary bioassay tests demonstrated that all the compounds have photoactivated insecticidal activity against Aedes albopictus. The compound 5l showed the highest activity with LC₅₀ 0.04 μg/mL when exposed to light, which is similar to commercial available fipronil.

Key words: N-aryl pyrazole, thiophene, photoactivation, insecticidal activity

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YUAN Li-Qing, XU Han-Hong, YANG Wen, LI Na. Synthesis and Photoactivated Activity of Thiophene Conjugated with N-Aryl Pyrazole Derivatives[J]. Chin. J. Org. Chem., 2011, 31(9): 1452-1459.

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噻吩N-芳基吡唑类化合物的合成及光活化活性研究

Synthesis and Photoactivated Activity of Thiophene Conjugated with N-Aryl Pyrazole Derivatives

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