Syntheses and Characterization of 5-Alkoxy-4-cycloamino-3- halo-5H-furan-2-one

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (9): 1460-1467. Previous Articles Next Articles

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5-烷氧基-4-环胺基-3-卤-2(5H)-呋喃酮的合成与表征

傅建花¹，汪朝阳*^{,1，郝志峰²，霍景沛¹}

(¹华南师范大学化学与环境学院广州 510006)
(²广东工业大学轻工化工学院广州 510006)

收稿日期:2011-01-10 修回日期:2011-04-03 发布日期:2011-04-27
通讯作者: 汪朝阳 E-mail:wangwangzhaoyang@tom.com

Syntheses and Characterization of 5-Alkoxy-4-cycloamino-3- halo-5H-furan-2-one

Fu Jianhua¹ Wang Zhaoyang*^,1 Hao Zhifeng² Huo Jingpei¹

(¹ School of Chemistry and Environment, South China Normal University, Guangzhou 510006)
(² Faculty of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006)

Received:2011-01-10 Revised:2011-04-03 Published:2011-04-27
Contact: Zhaoyang Wang E-mail:wangwangzhaoyang@tom.com

Using cyclic secondary amines as nucleophilic reagents, the tandem Michael addition-elimination of 5-alkoxy-3,4-dihalo-5H-furan-2-one in the presence of potassium fluoride gave 17 novel compounds. The chemical structures and absolute configurations of the new compounds were confirmed via rotation, UV-Vis, IR, ¹H NMR, ¹³C NMR, MS, elemental analysis and X-ray single crystal diffraction.

Key words: 5-alkoxy-3,4-dihalo-5H-furan-2-one, cyclic secondary amine, Michael addition, tandem reac-tion, 5-alkoxy-4-cycloamino-3-halo-5H-furan-2-one, synthesis

Cite this article

FU Jian-Hua, WANG Chao-Yang, HAO Zhi-Feng, HUO Jing-Pei. Syntheses and Characterization of 5-Alkoxy-4-cycloamino-3- halo-5H-furan-2-one[J]. Chin. J. Org. Chem., 2011, 31(9): 1460-1467.

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5-烷氧基-4-环胺基-3-卤-2(5H)-呋喃酮的合成与表征

Syntheses and Characterization of 5-Alkoxy-4-cycloamino-3- halo-5H-furan-2-one

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